Document Detail

Increased serum levels of interleukin 6 are associated with severe intraventricular haemorrhage in extremely premature infants.
MedLine Citation:
PMID:  14602698     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intraventricular haemorrhage (IVH) and periventricular leucomalacia (PVL) in premature infants presumably have many causes. It has been proposed that inflammatory processes in the fetomaternal unit play an important role in the pathogenesis of these lesions. OBJECTIVE: To study the correlation of postpartum serum interleukin 6 (IL6) concentration as a marker of inflammation and neonatal cerebral morbidity in preterm infants < 28 weeks of gestational age. METHODS: A total of 88 infants were grouped according to maximum serum IL6 levels within 12 hours post partum: group A (n = 50), < or = 100 pg/ml; group B (n = 38), > 100 pg/ml. Ultrasound studies and clinical assessment were performed routinely. RESULTS: IVH was noted significantly more often in group B (24/38; 63%) than in group A (19/50; 38%) (p = 0.02). In a multiple logistic regression model, raised serum IL6 independently predicted development of severe IVH (odds ratio 8.4; 95% confidence interval 2.85 to 24.9; p = 0.0001). CONCLUSIONS: Raised serum IL6 may serve as a marker for severe IVH in infants < 28 weeks of gestational age. Although cerebral morbidity in premature infants is determined by different variables, the identification of systemic inflammation can help to define the need for anti-inflammatory strategies to prevent cerebral morbidity.
A Heep; D Behrendt; P Nitsch; R Fimmers; P Bartmann; J Dembinski
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  88     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-06     Completed Date:  2003-12-10     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F501-4     Citation Subset:  AIM; IM    
Department of Neonatology, Informatics and Epidemiology, University of Bonn, Germany.
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MeSH Terms
Catecholamines / adverse effects
Cerebral Hemorrhage / blood*,  mortality
Cohort Studies
Gestational Age
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood*,  mortality
Interleukin-6 / blood*
Leukocyte Count
Retrospective Studies
Risk Factors
Reg. No./Substance:
0/Catecholamines; 0/Interleukin-6

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