| Increased serum high-density lipoprotein-cholesterol concentration in celiac disease after gluten-free diet treatment correlates with body fat stores. | |
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MedLine Citation:
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PMID: 19809359 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low high-density lipoprotein-cholesterol (HDL-C) concentration correlates with increased cardiovascular risk. A great prevalence of celiac disease (CD) was reported among patients with low HDL-C concentration, and gluten-free diet (GFD) treatment seems to normalize lipid profile. We evaluated blood lipids and body composition in 26 CD patients with low HDL-C level (<1.0 mmol/L) at diagnosis and after GFD. STUDY: A case-control study. METHODS: The diagnosis was based on histologic evidence of subtotal or total duodenal villous atrophy. Patients were studied before and after GFD treatment (14.2+/-1.4 mo) with biopsy-proven return to normal of the duodenal mucosa. HDL-C was enzymatically assessed after precipitation of very low-density lipoprotein and low-density lipoprotein with heparin-magnesium. Apolipoprotein (Apo)-AI level was assessed by immunoturbidimetric assay; triglycerides by an enzymatic colorimetric method. Body composition was assessed by dual-energy x-ray absorptiometry. RESULTS: Body composition improved after GFD, with increasing body weight (P<0.05) essentially owing to increased fat mass (FM) (P<0.01), rather than fat-free mass (P=0.064). Total cholesterol and HDL-C were lower in untreated compared with treated patients (P<0.001 and P<0.0001). Apo-AI level increased significantly after GFD (1.20+/-0.22 vs. 1.46+/-0.17 g/L; P<0.0001). Apo-AI, sex, and FM were all significant determinants of HDL-C level; a positive correlation (R=0.68; P<0.0001) was found between increase in HDL-C level and in FM after GFD treatment. CONCLUSIONS: Restoration of lipid profile in CD patients after GFD treatment may be explained by an increase in both Apo-AI secretion by intestinal cells and body fat stores. |
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Authors:
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Esmeralda Capristo; Noemi Malandrino; Sara Farnetti; Geltrude Mingrone; Lorenzo Leggio; Giovanni Addolorato; Giovanni Gasbarrini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical gastroenterology Volume: 43 ISSN: 1539-2031 ISO Abbreviation: J. Clin. Gastroenterol. Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-01-25 Revised Date: 2010-08-26 |
Medline Journal Info:
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Nlm Unique ID: 7910017 Medline TA: J Clin Gastroenterol Country: United States |
Other Details:
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Languages: eng Pagination: 946-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Catholic University, Rome, Italy. e.capristo@rm.unicatt.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon
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methods Adipose Tissue / metabolism* Apolipoprotein A-I / metabolism* Body Composition Case-Control Studies Celiac Disease / diet therapy*, metabolism Cholesterol, HDL / blood Diet, Gluten-Free* Female Follow-Up Studies Humans Intestines / cytology, metabolism Male Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Cholesterol, HDL |
| Comments/Corrections | |
Comment In:
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J Clin Gastroenterol. 2010 Sep;44(8):592; author reply 592-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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