| Increased serum hepcidin levels during treatment with deferasirox in iron-overloaded patients with myelodysplastic syndrome. | |
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MedLine Citation:
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PMID: 21332711 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hepcidin is a major regulator of iron metabolism. We evaluated changes in serum hepcidin during 3 months of therapy with the iron-chelator deferasirox in patients with low-risk myelodysplastic syndrome and iron overload. Serum hepcidin was found to be high in these patients, correlated with their iron and oxidative status, and further increased by treatment with deferasirox. These findings support the concept that the hepcidin level represents a balance between the stimulating effect of iron overload and the inhibitory effects of erythropoietic activity and oxidative stress. These preliminary findings favour the rationale for iron chelation therapy in such patients. |
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Authors:
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Hussam Ghoti; Eitan Fibach; Mark Westerman; Olbina Gordana; Tomas Ganz; Eliezer A Rachmilewitz |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-20 |
Journal Detail:
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Title: British journal of haematology Volume: - ISSN: 1365-2141 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Haematology, Edith Wolfson Medical Centre, Holon Department of Haematology, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel Intrinsic LifeSciences LLC, La Jolla Department of Medicine, David Geffen School of Medicine, Los Angeles, CA, USA. |
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