| Increased serum granulocyte colony-stimulating factor correlates with coronary artery dilatation in Kawasaki disease. | |
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MedLine Citation:
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PMID: 12297900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In acute-phase Kawasaki disease, neutrophils cause injury to the coronary arterial endothelium through the production of elastase. Previous research has demonstrated the modulation of neutrophil function and kinetics, such as development and maturation, by granulocyte colony-stimulating factor (G-CSF). To examine the correlation between G-CSF and cardiac complications in Kawasaki disease, functional activity of serum G-CSF and cytokines was measured by enzyme-linked immunosorbent assay in 30 patients with acute-phase Kawasaki disease aged 2 months to 5 years. The mean serum G-CSF was higher in the 1st week of Kawasaki disease than during weeks 2 to 4, and G-CSF was significantly higher in patients with coronary artery dilatation (CAL) than in those without. There was no significant difference in the activity of other cytokines studied or white blood cell counts between the patients with CAL. Conclusion: granulocyte colony-stimulating factor is correlated with coronary artery dilatation in acute-phase Kawasaki disease and increased neutrophil function may contribute to the pathogenesis of coronary arterial endothelial injury in these patients. |
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Authors:
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Kazunori Samada; Hiroshi Igarashi; Hirohiko Shiraishi; Kiyohiko Hatake; Mariko Y Momoi |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2002-08-16 |
Journal Detail:
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Title: European journal of pediatrics Volume: 161 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-09-25 Completed Date: 2003-03-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 538-41 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Jichi Medical School, 3311-1 Yakushiji, Minamikawachi, Tochigi 329-0498, Japan. ksamada@jichi.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Arteries
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metabolism*,
pathology* Biological Markers / blood Child Welfare Child, Preschool Coronary Vessels / metabolism*, pathology* Dilatation, Pathologic / blood*, complications Female Granulocyte Colony-Stimulating Factor / blood* Humans Infant Infant Welfare Interleukin-6 / blood Japan Male Mucocutaneous Lymph Node Syndrome / blood*, complications Statistics as Topic |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-6; 143011-72-7/Granulocyte Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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