| Increased serum concentrations of adhesion molecules but not of chemokines in patients with Type 2 diabetes compared with patients with Type 1 diabetes and latent autoimmune diabetes in adult age: Action LADA 5. | |
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MedLine Citation:
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PMID: 22150724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: Systemic concentrations of adhesion molecules and chemokines are associated with increased risk of cardiovascular complications. We compared these factors between patients with Type 2 diabetes vs. Type 1 diabetes or latent autoimmune diabetes in adults. Methods: Serum concentrations of adhesion molecules sE-selectin, sICAM-1 and sVCAM-1, and chemokines CCL2, CCL3 and CCL4 were measured in 61 patients with latent autoimmune diabetes in adults, 90 with Type 1 diabetes, 465 with Type 2 diabetes and in 41 control subjects, using multiple regression models to adjust for possible confounders. Results: Patients with Type 2 diabetes exhibited greater concentrations of adhesion molecules (P < 0.02) than those with Type 1 diabetes, latent autoimmune diabetes in adults and control subjects. These differences persisted upon adjustments for age, sex, BMI, blood pressure and diabetes duration (P < 0.04). Higher BMI positively correlated with concentrations of adhesion molecules in all subjects (P < 0.0001). Concentrations of sE-selectin positively related to diastolic (β = 0.31) and systolic (β = 0.28) blood pressure in the adjusted model (P < 0.04). Concentrations of the chemokines, CCL2 and CCL4, did not differ between groups, while CCL3 was higher in patients with latent autoimmune diabetes in adults and Type 1 diabetes than in those with Type 2 diabetes and control subjects (P < 0.05). Conclusions: Systemic concentrations of adhesion molecules, but not chemokines, relate to cardiovascular risk factors, but remain higher after adjustments in Type 2 diabetes, suggesting a diabetes-type specific effect without difference between latent autoimmune diabetes in adults and Type 1 diabetes, despite their dissimilar phenotype. © 2011 The Authors. Diabetic Medicine© 2011 Diabetes UK. |
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Authors:
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M N Pham; M I Hawa; M Roden; G Schernthaner; P Pozzilli; R Buzzetti; W A Scherbaum; J Seissler; S Hunter; R D G Leslie; H Kolb; N C Schloot; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-12 |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: - ISSN: 1464-5491 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. |
Affiliation:
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Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich-Heine University, Düsseldorf, Germany Blizard Institute of Cell and Molecular Science, London, UK Department of Metabolic Diseases, Heinrich-Heine University, Düsseldorf, Germany Department of Medicine I, Rudolfstiftung Hospital, Vienna, Austria Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome Department of Clinical Science, Sapienza University Rome, Rome, Italy Department of Endocrinology, Diabetes and Rheumatology, Heinrich-Heine University, Düsseldorf Diabetes Center, Medical Clinic-Innenstadt, Ludwig-Maximillians-University, Munich, Germany Department of Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital, Belfast, UK Department of Immunobiology Heinrich-Heine University, Düsseldorf, Germany. |
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