Document Detail

Increased serum concentration of eosinophil-derived neurotoxin in patients with Graves' disease.
MedLine Citation:
PMID:  12699586     Owner:  NLM     Status:  MEDLINE    
Eosinophil-derived neurotoxin (EDN) is released after activation and stimulation of eosinophils in allergic disease, which is a T(H)2-predominant condition. We previously reported that Graves' thyrotoxicosis develops or relapses after an attack of allergic rhinitis. In this study, to confirm the relation between Graves' disease and the allergic condition, we determined the serum level of EDN in 30 untreated patients with Graves' disease, 50 patients with Hashimoto's thyroiditis, and 39 normal controls. Compared to the serum level in normal subjects (30.1 +/- 15.6 ng/mL), EDN was increased in untreated patients with Graves' disease (52.4 +/- 27.6 ng/mL), but not in patients with Hashimoto's thyroiditis (thyrotoxic, 30.9 +/- 13.4 ng/mL; euthyroid, 30.0 +/- 11.9 ng/mL; hypothyroid, 23.4 +/- 10.2 ng/mL). A significant correlation was observed between the EDN level and the serum activity of thyrotropin (TSH) receptor antibody (r = 0.541, p < 0.0001). These data suggest that the allergic condition is closely related to Graves' disease and that a T(H)2-type immune response is crucial in the pathogenesis of Graves' disease.
Yoh Hidaka; Masahiro Kimura; Yukiko Izumi; Toru Takano; Ke-ita Tatsumi; Nobuyuki Amino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  13     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-04-17     Completed Date:  2003-10-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
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MeSH Terms
Biological Markers
Eosinophil-Derived Neurotoxin
Graves Disease / blood*,  complications*,  immunology
Middle Aged
Receptors, Thyrotropin / physiology
Rhinitis, Allergic, Seasonal / blood,  complications*,  immunology
Ribonucleases / blood*,  immunology*
Th2 Cells / immunology
Thyroiditis, Autoimmune / blood,  immunology
Thyrotropin / metabolism
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Thyrotropin; 9002-71-5/Thyrotropin; EC 3.1.-/Eosinophil-Derived Neurotoxin; EC 3.1.-/Ribonucleases
Comment In:
Thyroid. 2003 Feb;13(2):127-8   [PMID:  12699602 ]

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