| Increased serum apolipoprotein(a) in patients with chronic renal failure treated with continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 1596303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with end-stage renal failure (ESRF) on renal replacement therapy are at significantly increased risk of cardiovascular disease. To determine whether altered concentrations of apolipoprotein(a) (apo(a)), the plasminogen-like protein moiety of the atherogenic particle lipoprotein(a), contributed to this increased risk, apo(a) concentrations were measured in 48 non-diabetic patients with ESRF treated by continuous ambulatory peritoneal dialysis (CAPD) therapy and compared with 65 controls. Apo(a) concentration was increased in CAPD patients compared to controls (geometric mean 419 units/l versus 137 units/l; ratio of means 3.06 (95% CI 1.95-4.80). We conclude that CAPD patients have increased apo(a) concentrations which may contribute to their increased risk of cardiovascular disease. |
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Authors:
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B G Murphy; P McNamee; E Duly; W Henry; P Archbold; T Trinick |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Atherosclerosis Volume: 93 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-07-01 Completed Date: 1992-07-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 53-7 Citation Subset: IM |
Affiliation:
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Regional Nephrology Unit, Belfast City Hospital, Northern Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Apolipoproteins / blood* Apoprotein(a) Cholesterol / blood Female Humans Kidney Failure, Chronic / blood*, therapy Lipoprotein(a)* Male Peritoneal Dialysis, Continuous Ambulatory* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Lipoprotein(a); 0/Triglycerides; 57-88-5/Cholesterol; EC 3.4.21.-/Apoprotein(a) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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