| Increased serum apolipoprotein B48 concentration in patients with metabolic syndrome. | |
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MedLine Citation:
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PMID: 19713673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: Postprandial hyperlipidemia is characterized by an increase of chylomicron remnants (CM-R), and is a risk factor for atherosclerosis. Apolipoprotein (apo) B48 exists exclusively in chylomicroms and CM-R, and fasting plasma levels of apo B48 may reflect high postprandial levels of chylomicrons and/or CM-R. We hypothesized that fasting apo B48 levels may be increased in metabolic syndrome. METHODS: We investigated 1,349 inhabitants (528 men and 821 women aged 62.4+/-12.8 y; mean+/-S.D.) of two towns in rural Hokkaido, who underwent health checks in 2005. RESULTS: The fasting apo B48 level was significantly higher in males than females (geometric mean 1.92; 95% CI 1.802.04 microg/mL, vs. 1.69; 95% CI 1.611.76 microg/mL; p< 0.001). Ln (apo B48) showed a significant positive correlation with total cholesterol and ln (triglycerides), and a negative correlation with HDL-cholesterol. The correlation between ln (apo B48) and ln (triglycerides) was strong. Apo B48 was significantly higher in men and women with than without metabolic syndrome. Regression analysis revealed that ln (apo B48) was significantly associated with age, BMI, total cholesterol, HDL cholesterol, LDL cholesterol, and ln (triglyceride). CONCLUSION: Fasting apo B48 levels are raised in individuals with metabolic syndrome. |
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Authors:
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Makoto Kinoshita; Hirofumi Ohnishi; Tomomi Maeda; Nakayuki Yoshimura; Yoko Takeoka; Daijiro Yasuda; Jun Kusano; Yamato Mashimo; Shigeyuki Saito; Kazuaki Shimamoto; Tamio Teramoto |
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Publication Detail:
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Type: Journal Article Date: 2009-08-27 |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 16 ISSN: 1880-3873 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-09-16 Completed Date: 2009-12-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 517-22 Citation Subset: IM |
Affiliation:
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Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan. makkino@med.teikyo-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoprotein B-48 / blood* Cholesterol / blood Cholesterol, HDL / blood Fasting Female Humans Male Metabolic Syndrome X / blood* Middle Aged Risk Factors Sex Factors Triglycerides / blood Up-Regulation |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein B-48; 0/Cholesterol, HDL; 0/Triglycerides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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