| Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction. | |
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MedLine Citation:
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PMID: 19527302 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Inflammation caused by activated macrophages and T lymphocytes may trigger plaque rapture in acute coronary syndrome (ACS). Anandamide and 2-arachidonylglycerol (2-AG) are macrophage-derived signal lipids and may be involved in the pathogenesis of ACS, but no clinical relevant data have been reported. In 43 acute myocardial infarction (AMI) patients (66 +/- 2 years), blood samples were obtained from the aortic root and the infarct-related coronary artery (IRA) using a PercuSurge system during primary percutaneous coronary intervention (PCI). In six patients with stable effort angina (SEA) (56 +/- 6 years), blood samples were obtained from the site of stenosis during elective PCI. In 25 of the 43 AMI patients, anandamide was detected in the serum. Serum anandamide level was 35 +/- 20 pmol/mL in the aorta and was significantly increased to 401 +/- 134 pmol/mL in the IRA (P < 0.01). 2-AG was undetectable in most of the patients. In patients with SEA, neither anandamide nor 2-AG was detected in the serum at the plaque site. In AMI patients with anandamide detected, left ventricular ejection fraction at 2 weeks after PCI was increased by 3.7 +/- 2.1% compared with that at the acute phase, while it was decreased by 3.0 +/- 1.8% in those without anandamide detected (P < 0.05). The serum anandamide level at the culprit lesion was elevated compared with the systemic level in a significant number of AMI patients, indicating the synthesis of anandamide at the IRA. Anandamide was suggested to be derived from ruptured plaque and may exert beneficial effects in humans. |
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Authors:
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Naotaka Maeda; Tomohiro Osanai; Motoi Kushibiki; Takayuki Fujiwara; Yujin Tamura; Shingen Oowada; Takumi Higuma; Shingo Sasaki; Jin Yokoyama; Fuminobu Yoshimachi; Toshiro Matsunaga; Hiroyuki Hanada; Ken Okumura |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Fundamental & clinical pharmacology Volume: 23 ISSN: 1472-8206 ISO Abbreviation: Fundam Clin Pharmacol Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-08-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710411 Medline TA: Fundam Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 351-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / physiopathology Angioplasty, Transluminal, Percutaneous Coronary Aorta / physiopathology Arachidonic Acids / biosynthesis, blood* Coronary Vessels / physiopathology* Female Glycerides / blood Humans Inflammation / etiology, physiopathology Male Middle Aged Myocardial Infarction / physiopathology* Polyunsaturated Alkamides / blood* Rupture, Spontaneous |
| Chemical | |
Reg. No./Substance:
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0/Arachidonic Acids; 0/Glycerides; 0/Polyunsaturated Alkamides; 53847-30-6/2-arachidonylglycerol; 94421-68-8/anandamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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