Document Detail


Increased serum anandamide level at ruptured plaque site in patients with acute myocardial infarction.
MedLine Citation:
PMID:  19527302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Inflammation caused by activated macrophages and T lymphocytes may trigger plaque rapture in acute coronary syndrome (ACS). Anandamide and 2-arachidonylglycerol (2-AG) are macrophage-derived signal lipids and may be involved in the pathogenesis of ACS, but no clinical relevant data have been reported. In 43 acute myocardial infarction (AMI) patients (66 +/- 2 years), blood samples were obtained from the aortic root and the infarct-related coronary artery (IRA) using a PercuSurge system during primary percutaneous coronary intervention (PCI). In six patients with stable effort angina (SEA) (56 +/- 6 years), blood samples were obtained from the site of stenosis during elective PCI. In 25 of the 43 AMI patients, anandamide was detected in the serum. Serum anandamide level was 35 +/- 20 pmol/mL in the aorta and was significantly increased to 401 +/- 134 pmol/mL in the IRA (P < 0.01). 2-AG was undetectable in most of the patients. In patients with SEA, neither anandamide nor 2-AG was detected in the serum at the plaque site. In AMI patients with anandamide detected, left ventricular ejection fraction at 2 weeks after PCI was increased by 3.7 +/- 2.1% compared with that at the acute phase, while it was decreased by 3.0 +/- 1.8% in those without anandamide detected (P < 0.05). The serum anandamide level at the culprit lesion was elevated compared with the systemic level in a significant number of AMI patients, indicating the synthesis of anandamide at the IRA. Anandamide was suggested to be derived from ruptured plaque and may exert beneficial effects in humans.
Authors:
Naotaka Maeda; Tomohiro Osanai; Motoi Kushibiki; Takayuki Fujiwara; Yujin Tamura; Shingen Oowada; Takumi Higuma; Shingo Sasaki; Jin Yokoyama; Fuminobu Yoshimachi; Toshiro Matsunaga; Hiroyuki Hanada; Ken Okumura
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fundamental & clinical pharmacology     Volume:  23     ISSN:  1472-8206     ISO Abbreviation:  Fundam Clin Pharmacol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710411     Medline TA:  Fundam Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  351-7     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina Pectoris / physiopathology
Angioplasty, Transluminal, Percutaneous Coronary
Aorta / physiopathology
Arachidonic Acids / biosynthesis,  blood*
Coronary Vessels / physiopathology*
Female
Glycerides / blood
Humans
Inflammation / etiology,  physiopathology
Male
Middle Aged
Myocardial Infarction / physiopathology*
Polyunsaturated Alkamides / blood*
Rupture, Spontaneous
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Glycerides; 0/Polyunsaturated Alkamides; 53847-30-6/2-arachidonylglycerol; 94421-68-8/anandamide

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