| Increased sensitivity of flow detection in the left coronary artery by transesophageal echocardiography after intravenous administration of transpulmonary stable echocontrast agent. | |
| | |
MedLine Citation:
|
PMID: 7917340 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Transesophageal echocardiography (TEE) combined with color and pulsed Doppler allows a noninvasive assessment of flow in the proximal anterior descending coronary artery (LAD). The aim of this study was to assess whether the peripheral administration of a transpulmonary stable echocontrast agent with prolonged in vivo stability may improve the feasibility and accuracy of coronary flow detection by TEE Doppler. In 12 out of 14 consecutive patients undergoing routine diagnostic TEE examination, color-coded images of left main coronary artery (LM) and the origin of the LAD and circumflex artery (CXA), as well as spectral Doppler signals from the LAD, were evaluated before and after intravenous injection of SHU 508 A. After administration of echocontrast material, the coronary Doppler signal (both color-coded and spectral) was enhanced for approximately 100 seconds. The length and diameter of color-coded flow increased significantly in the LM, LAD, and CXA. (The length of color-coded flow before and after injection of contrast material were the following: in LM 0.94 +/- 0.44 versus 1.39 +/- 0.52 cm, p < 0.001; in LAD 0.68 +/- 0.36 versus 1.20 +/- 0.41 cm, p < 0.001; and in CXA 0.54 +/- 0.20 versus 1.06 +/- 0.86 cm; in this artery, color-coded flow was visualized only in six patients before and 11 patients after injection of contrast material. The corresponding values for the diameters of color-coded flow in LM were 0.36 +/- 0.08 versus 0.46 +/- 0.09 cm, p < 0.001; in LAD 0.29 +/- 0.07 versus 0.41 +/- 0.1 cm, p < 0.002; and in CXA 0.26 +/- 0.05 versus 0.40 +/- 0.04 cm.) By pulsed Doppler, significant increments in peak diastolic (47.8 +/- 21.3 versus 37.2 +/- 14.5 cm/sec, p < 0.05), mean diastolic (37.4 +/- 14.7 versus 27.9 +/- 8.4 cm/sec, p < 0.005), mean systolic flow velocity (23.2 +/- 6.8 versus 19.0 +/- 4.7 cm/sec, p < 0.005), and diastolic (11.0 +/- 3.9 versus 7.7 +/- 3.0 cm, p < 0.001) and total flow integral (16.8 +/- 5.3 versus 10.5 +/- 4.6 cm, p < 0.001) were observed. By contrast, peak systolic velocity did not increase. However, the systolic component of coronary flow, detectable in 7 out of 12 patients before injection of contrast material, became detectable in all 12 patients after injection of contrast material.(ABSTRACT TRUNCATED AT 400 WORDS) |
| | |
Authors:
|
M Kozàkovà; C Palombo; M Zanchi; A Distante; A L'Abbate |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: 7 ISSN: 0894-7317 ISO Abbreviation: J Am Soc Echocardiogr Publication Date: 1994 Jul-Aug |
Date Detail:
|
Created Date: 1994-11-10 Completed Date: 1994-11-10 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 327-36 Citation Subset: IM |
Affiliation:
|
National Research Council, Institute of Clinical Physiology, Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Flow Velocity / physiology Contrast Media / administration & dosage* Coronary Circulation / physiology* Coronary Vessels / physiology, ultrasonography* Echocardiography, Doppler, Color Echocardiography, Doppler, Pulsed Echocardiography, Transesophageal* Feasibility Studies Female Humans Image Enhancement Injections, Intravenous Male Middle Aged Polysaccharides / diagnostic use* Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
|
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cell cycle regulated transcription in yeast.
Next Document: Myocardial contrast enhancement after intravenous injection of sonicated albumin microbubbles: a tra...