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Increased risk of trigeminal neuralgia after hypertension: A population-based study.
MedLine Citation:
PMID:  21998318     Owner:  NLM     Status:  Publisher    
OBJECTIVE:Very few studies have explored the temporal relationship between hypertension and trigeminal neuralgia (TN). The aim of this population-based follow-up study was to investigate whether hypertension is associated with a higher risk of developing TN. METHODS:A total of 138,492 persons with at least 2 ambulatory visits with the principal diagnosis of hypertension in 2001 were enrolled in the hypertension group. The nonhypertension group consisted of 276,984 age- and sex-matched, randomly sampled subjects without hypertension. The 3-year TN-free survival rate and the cumulative incidence of TN were calculated using the Kaplan-Meier method. Cox proportional hazard regression was used to estimate the hazard ratio of TN. RESULTS:In the hypertension group, 121 patients developed TN during follow-up, while, in the nonhypertension group, 167 subjects developed TN. The crude hazard ratio for the hypertension group was 1.52 (95% confidence interval [CI] 1.20-1.92; p = 0.0005), while, after adjustment for demographic characteristics and medical comorbidities, the adjusted hazard ratio was 1.51 (95% CI 1.19-1.90; p = 0.0006). CONCLUSIONS:This study shows a significantly increased risk of developing TN after hypertension. Further studies are needed to elucidate the underlying mechanism of the association between hypertension and TN.
S-L Pan; M-F Yen; Y-H Chiu; L-S Chen; H-H Chen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-12
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Physical Medicine and Rehabilitation (S.-L.P.), National Taiwan University Hospital and National Taiwan University College of Medicine (S.-L.P.), Taipei; School of Oral Hygiene (M.F.-Y., L.-S.C.), College of Oral Medicine, Taipei Medical University, Taipei; Department and Graduate Institute of Health Care Management (Y.-H.C.), Chang Gung University, Tao-Yuan; and Centre of Biostatistics Consultation (H.-H.C.) and Division of Biostatistics, Graduate Institute of Epidemiology (H.-H.C.), College of Public Health, National Taiwan University, Taipei, Taiwan.
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