| Increased risk of symptomatic gallbladder disease in adults with Down syndrome. | |
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MedLine Citation:
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PMID: 15386474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous reports have documented an increased prevalence of asymptomatic cholelithiasis among children with Down syndrome. Whether this predisposes adults with Down syndrome to symptomatic gallbladder disease has not been studied. A case control study compared the rate of symptomatic gallbladder disease in 28 index cases of adults with Down syndrome and that of sex-matched controls. The rate of gallbladder disease was 25% among the Down syndrome group, compared to 4.5% among the control group (P = 0.002). Patients with Down syndrome were also more likely to have a family medical history of gallbladder disease. Utilizing logistic regression analysis, the adjusted relative risk for gallbladder disease among individuals with Down syndrome was 3.52. |
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Authors:
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Carl V Tyler; Stephen J Zyzanski; Lloyd Runser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of medical genetics. Part A Volume: 130A ISSN: 1552-4825 ISO Abbreviation: Am. J. Med. Genet. A Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-29 Completed Date: 2005-03-02 Revised Date: 2008-05-21 |
Medline Journal Info:
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Nlm Unique ID: 101235741 Medline TA: Am J Med Genet A Country: United States |
Other Details:
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Languages: eng Pagination: 351-3 Citation Subset: IM |
Copyright Information:
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(c) 2004 Wiley-Liss, Inc. |
Affiliation:
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Fairview/Cleveland Clinic Family Practice Residency, 18200 Lorain Avenue, Cleveland, OH 44111, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Case-Control Studies Cholelithiasis / etiology*, genetics* Down Syndrome / complications* Female Humans Male Middle Aged Risk Factors |
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