| Increased risk of stroke after spinal cord injury: A nationwide 4-year follow-up cohort study. | |
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MedLine Citation:
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PMID: 22377807 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:Spinal cord injury (SCI) is associated with a higher risk of cardiovascular diseases but whether or not the risk of cerebrovascular disease also increases remains unclear. This study aimed to evaluate the incidence of stroke in patients with disability caused by SCI. METHODS:Study subjects were identified from a nationwide cohort of 18,690,066 people from 1998 to 2002 that was divided into an SCI group (n = 2,806), who were disabled from SCI, and a comparison group (n = 28,060), composed of age-, sex-, and propensity score- matched control subjects. Every subject was followed up for 4 years, unless they died or had a stroke by December 31, 2006. Kaplan-Meier and Cox regression analyses were performed. RESULTS:The incidence rate of stroke in the SCI group (5.96 per 1,000 person-years) was higher than that of the comparison group (p < 0.001). Stroke was more likely to occur in the SCI group than in the comparison group (crude hazard ratio 2.93, p < 0.001; adjusted hazard ratio 2.85, p < 0.001). In the SCI group, the incidence of ischemic stroke was higher than that of hemorrhagic stroke (incidence rate ratio 3.42, p < 0.001). CONCLUSIONS:SCI patients with disability are at a higher risk of stroke, especially the ischemic type. Strategies to prevent stroke are therefore suggested for them. |
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Authors:
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J-C Wu; Y-C Chen; L Liu; T-J Chen; W-C Huang; H Cheng; T-P Su |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-29 |
Journal Detail:
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Title: Neurology Volume: - ISSN: 1526-632X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Department of Neurosurgery (J.-C.W., W.C.-H., H.C.), Neurological Institute, Taipei Veterans General Hospital, Taipei; School of Medicine (J.-C.W., W.C.-H., H.C., T.-P.S.), Institute of Pharmacology (J.-C.W., H.C.), and Institute of Hospital and Health Care Administration (Y.-C.C., T.-J.C.), National Yang-Ming University, Taipei; Department of Medical Research and Education (Y.-C.C.), National Yang-Ming University Hospital, I-Lan; and Department of Ophthalmology (L.L.), Chang Gung Memorial Hospital, Taoyuan; College of Medicine (L.L.), Chang Gung University, Taoyuan, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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