| Increased risk of relapse after stopping nicotine replacement therapies: a mathematical modelling approach. | |
| | |
MedLine Citation:
|
PMID: 15679754 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIMS: To describe the effect of nicotine replacement therapy (NRT) on the risk of relapse as a function of time since the quit date. DATA SOURCES: Meta-analysis of 21 published, randomized, controlled clinical trials, comparing NRT to placebo. DATA EXTRACTION: A total of 6644 smokers were treated with NRT and 2766 smokers treated with placebo. DATA SYNTHESIS: During treatment with the medication, NRT reduced the hazard ratio (HR) significantly compared with placebo [early HR = 0.62 (95% CI: 0.58-0.67)]. At the end of the average treatment duration (145 days), the HR was 0.81 (95% CI: 0.71-0.94), showing that the benefit was still present at this time. After stopping treatment, the HR increased progressively up to a value of 1.44 (95% CI, 1.18-1.76) showing that the risk of relapse was higher after stopping NRT than after stopping placebo. If NRT and placebo had not been stopped, the HR of smoking relapse would have been established at 0.95 (95% CI: 0.76-1.18, P = 0.64), indicating a similar risk of relapse with NRT and placebo. Moreover, the observed HR of smoking relapse was significantly higher than the expected HR of smoking relapse if NRT had been continued: the difference in HR is 1.51 (95% CI: 1.16-1.98, P < 0.003). This suggests that if NRT had been been continued, around 50% of relapses could have been prevented. CONCLUSION: The protective effect of NRT against relapse slowly decreases as a function of time. After stopping NRT, the risk of relapse increases. It may be more beneficial not to stop NRT after the usual 3-6-month treatment period but to use NRT for longer periods of time. |
| | |
Authors:
|
Jacques Medioni; Ivan Berlin; Alain Mallet |
Related Documents
:
|
468744 - Nicotine fading and self-monitoring for cigarette abstinence or controlled smoking. 18565634 - A randomized, controlled exposure study in adult smokers of full flavor marlboro cigare... 6802384 - Nicotine concentrations in urine and saliva of smokers and non-smokers. 15310234 - On the deposition of volatiles and semivolatiles from cigarette smoke aerosols: relativ... 23595554 - Monitoring agricultural rodenticide use and secondary exposure of raptors in scotland. 23247714 - Physical activity and cardiovascular disease in african americans in aric. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis |
Journal Detail:
|
Title: Addiction (Abingdon, England) Volume: 100 ISSN: 0965-2140 ISO Abbreviation: Addiction Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-01-31 Completed Date: 2005-06-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9304118 Medline TA: Addiction Country: England |
Other Details:
|
Languages: eng Pagination: 247-54 Citation Subset: IM |
Affiliation:
|
Centre d'Investigations Cliniques, Hôpital Saint Louis, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Female Follow-Up Studies Humans Male Models, Biological Nicotine / therapeutic use* Nicotinic Agonists / therapeutic use* Randomized Controlled Trials as Topic Recurrence Risk Factors Smoking / prevention & control* Withholding Treatment |
| Chemical | |
Reg. No./Substance:
|
0/Nicotinic Agonists; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does alcohol advertising promote adolescent drinking? Results from a longitudinal assessment.
Next Document: The effect of acid suppression on sleep patterns and sleep-related gastro-oesophageal reflux.