| Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study. | |
| | |
MedLine Citation:
|
PMID: 19740897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78%, P < 0.001) and SGA infants (19.00 versus 17.28%, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95% CI 1.19-1.46) and 1.16 (95% CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy. |
| | |
Authors:
|
Yi-Hua Chen; Herng-Ching Lin; Shu-Fen Chen; Hsiu-Chen Lin |
Related Documents
:
|
16524957 - Pregnancy outcomes, infant mortality, and arsenic in drinking water in west bengal, india. 20438917 - Is routine preoperative 2-dimensional echocardiography necessary for infants with esoph... 16856047 - Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of p... 20618317 - Reduced birthweight in short or primiparous mothers: physiological or pathological? 7422397 - Creatine kinase isoenzymes in high-risk infants. 11338317 - Air pollution and birth weight in britain in 1946. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-09-09 |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 24 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-17 Completed Date: 2010-02-12 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
|
Languages: eng Pagination: 3049-56 Citation Subset: IM |
Affiliation:
|
School of Public Health, Taipei Medical University, Taipei, Taiwan, Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Cohort Studies Databases, Factual Female Humans Infant Infant, Newborn Infant, Small for Gestational Age* Leiomyoma / complications* Middle Aged Pregnancy Pregnancy Complications, Neoplastic* Pregnancy Outcome / epidemiology Premature Birth / epidemiology* Registries Risk Statistics as Topic Taiwan / epidemiology Uterine Neoplasms / complications* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Does organic farming benefit farmland birds in winter?
Next Document: Early prenatal androgenization results in diminished ovarian reserve in adult female rhesus monkeys.