Document Detail

Increased risk of preterm births among women with uterine leiomyoma: a nationwide population-based study.
MedLine Citation:
PMID:  19740897     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Using a 3-year nationwide population-based database, this study examines the risk of adverse pregnancy outcomes [lower birthweight, preterm gestation and babies small for gestational age (SGA)] in pregnant women with uterine leiomyoma. METHODS: This study linked two data sets: Taiwan's birth certificate registry and its National Health Insurance Research Data set. A total of 5627 mothers with uterine leiomyoma and 28 135 unaffected mothers were included for analysis. After adjusting for mother and infant characteristics and monthly family income, log-binominal regression and multivariate regression analyses were conducted to examine the risks of preterm birth, SGA and lower birthweight among mothers with uterine leiomyoma and unaffected mothers. RESULTS: Women with uterine leiomyoma had a significantly higher percentage of preterm births (10.98 versus 7.78%, P < 0.001) and SGA infants (19.00 versus 17.28%, P = 0.002) than unaffected mothers. The mean birthweights for mothers with and without uterine leiomyoma were 3083 and 3172 g, respectively (P < 0.001). Log-binominal regression models show that the adjusted risk ratios of preterm births and SGA infants for mothers with uterine leiomyoma were 1.32 (95% CI 1.19-1.46) and 1.16 (95% CI 1.08-1.26), respectively, compared with unaffected mothers. After finally adjusting for gestational age and other covariates, a multivariate regression analysis revealed that women with uterine leiomyoma had, on average, a 14.7 g lower birthweight than unaffected mothers (P = 0.022). CONCLUSIONS: We concluded that after adjusting for potential confounders, women with uterine leiomyoma experience a small yet significant increased risk of preterm and SGA infants. We suggest that clinicians intensively monitor women with uterine leiomyoma during pregnancy.
Yi-Hua Chen; Herng-Ching Lin; Shu-Fen Chen; Hsiu-Chen Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-09
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  24     ISSN:  1460-2350     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-17     Completed Date:  2010-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  3049-56     Citation Subset:  IM    
School of Public Health, Taipei Medical University, Taipei, Taiwan, Republic of China.
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MeSH Terms
Cohort Studies
Databases, Factual
Infant, Newborn
Infant, Small for Gestational Age*
Leiomyoma / complications*
Middle Aged
Pregnancy Complications, Neoplastic*
Pregnancy Outcome / epidemiology
Premature Birth / epidemiology*
Statistics as Topic
Taiwan / epidemiology
Uterine Neoplasms / complications*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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