Document Detail


Increased risk of pertussis in adult patients with mannose-binding lectin deficiency.
MedLine Citation:
PMID:  23030784     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mannose-binding lectin (MBL) is an important molecule of the innate immunity. The low level of MBL in the serum is associated with increased susceptibility to respiratory infections. In this study, MBL concentrations were determined from the sera of 125 Finnish pertussis patients and from 430 control subjects. Severe MBL deficiency (<50 ng/mL) was found more often in the patients than in the controls (11.2% vs 5.8%, p = 0.038). Moreover, the deficiency was detected more frequently in the adult patients than in the controls [20.4% vs 8.6%, p = 0.021; odds ratio 2.7 (95% confidence interval 1.1-6.5)]. Our findings suggest, for the first time, that MBL deficiency predisposes to pertussis infection, at least in adults.
Authors:
Kirsi Gröndahl-Yli-Hannuksela; Markku Viander; Jussi Mertsola; Qiushui He
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-13
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  -     ISSN:  1600-0463     ISO Abbreviation:  APMIS     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors APMIS © 2012 APMIS.
Affiliation:
Department of Infectious Disease Surveillance and Control, National Institute for Health and Welfare, Turku, Finland.
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