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Increased risk of acute pancreatitis among tetracycline users in a Swedish population-based case-control study.
MedLine Citation:
PMID:  21957155     Owner:  NLM     Status:  Publisher    
ObjectiveTo evaluate the suggested association between tetracycline and acute pancreatitis in a large pharmacoepidemiological study.DesignThe use of tetracycline in relation to the risk of acute pancreatitis was examined in a nationwide case-control study of people aged 40-84 years between 2006 and 2008 in Sweden. The Swedish Patient Register was used to identify 6161 cases of first-episode acute pancreatitis. The Register of the Total Population was used to randomly select 61 637 control subjects from the general population using frequency-based density sampling, matched for age, sex, and calendar year. Tetracycline use was defined as 'current', 'recent', 'past' or 'former' if the drug had been dispensed 0-30 days, 31-180 days, 181-365 days or 1-3½ years before the index date, respectively. The risk of acute pancreatitis was estimated by unconditional logistic regression, providing ORs with 95% CIs, adjusted for potential confounding factors.ResultsThere was a 60% increased risk of acute pancreatitis among current users of tetracycline after adjustment for potential confounders (OR=1.6, 95% CI 1.2 to 2.1). There was no increased OR for any category of previous use.ConclusionCurrent use of tetracycline is associated with an increased risk of acute pancreatitis, verifying previous case reports.
Rickard Ljung; Jesper Lagergren; Tomas S Bexelius; Fredrik Mattsson; Mats Lindblad
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-27
Journal Detail:
Title:  Gut     Volume:  -     ISSN:  1468-3288     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
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