Document Detail

Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone.
MedLine Citation:
PMID:  18631328     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. METHODS: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. RESULTS: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). CONCLUSIONS: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.
Dag S Fosmark; Jens P Berg; Aase-Brith Jensen; Leiv Sandvik; Elisabet Agardh; Carl-David Agardh; Kristian F Hanssen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-09
Journal Detail:
Title:  Acta ophthalmologica     Volume:  87     ISSN:  1755-3768     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  498-500     Citation Subset:  IM    
Diabetes Research Centre, Aker and Ullevål University Hospitals, Oslo, Norway.
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MeSH Terms
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / blood*
Diabetic Retinopathy / blood*,  epidemiology*,  pathology
Fundus Oculi
Glycosylation End Products, Advanced / blood*
Hemoglobin A, Glycosylated / metabolism
Imidazoles / blood*
Middle Aged
Pyruvaldehyde / metabolism
Young Adult
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 0/Hemoglobin A, Glycosylated; 0/Imidazoles; 0/hemoglobin A1c protein, human; 0/imidazolone; 78-98-8/Pyruvaldehyde

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