Document Detail


Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone.
MedLine Citation:
PMID:  18631328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: We aimed to investigate associations between serum levels of the advanced glycation endproduct methylglyoxal-derived hydroimidazolone (MG-H1) and retinopathy in a sample of patients with type 1 diabetes. METHODS: We conducted a cross-sectional study in a Scandinavian ophthalmology outpatient clinic on 61 randomly selected patients with type 1 diabetes. Blood samples and retinal photographs were taken at the same visit. Serum levels of hydroimidazolone immunoreactivity were determined using an immunoassay, and levels of retinopathy were determined from seven standard field stereo photographs of each eye according to the ETDRS method. Results were compared between patients with and without retinopathy. RESULTS: Hydroimidazolone quartiles were significantly associated with retinopathy (p = 0.013). The most profound increase in occurrence of retinopathy was observed from the lowest to the second-lowest hydroimidazolone quartile. Adjusted for duration of diabetes using logistic regression, a significant difference in the presence of retinopathy was found when comparing the lowest quartile with the rest (p = 0.022). CONCLUSIONS: In our patients with type 1 diabetes, serum levels of hydroimidazolone were found to be associated with retinopathy. This is in keeping with findings in a larger sample of patients with type 2 diabetes.
Authors:
Dag S Fosmark; Jens P Berg; Aase-Brith Jensen; Leiv Sandvik; Elisabet Agardh; Carl-David Agardh; Kristian F Hanssen
Related Documents :
9375578 - Mapping of retinal function in diabetic retinopathy using the multifocal electroretinog...
20212888 - Lasers in ophthalmology: the path from theory to application.
15675198 - The effect of post prandial glucose changes on oscillatory potentials in subjects with ...
756468 - Immune complexes and diabetic microangiopathy.
7817388 - Three types of "mid-band" lipoproteins in non-insulin-dependent diabetes mellitus: rela...
20001678 - Meta-analysis of the benefits of self-monitoring of blood glucose on glycemic control i...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-09
Journal Detail:
Title:  Acta ophthalmologica     Volume:  87     ISSN:  1755-3768     ISO Abbreviation:  -     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-11     Completed Date:  2009-11-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468102     Medline TA:  Acta Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  498-500     Citation Subset:  IM    
Affiliation:
Diabetes Research Centre, Aker and Ullevål University Hospitals, Oslo, Norway. dag.fosmark@medisin.uio.no
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cross-Sectional Studies
Diabetes Mellitus, Type 1 / blood*
Diabetic Retinopathy / blood*,  epidemiology*,  pathology
Female
Fundus Oculi
Glycosylation End Products, Advanced / blood*
Hemoglobin A, Glycosylated / metabolism
Humans
Imidazoles / blood*
Immunoassay
Male
Middle Aged
Prevalence
Pyruvaldehyde / metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 0/Hemoglobin A, Glycosylated; 0/Imidazoles; 0/hemoglobin A1c protein, human; 0/imidazolone; 78-98-8/Pyruvaldehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Macular microcirculation in hypertensive patients with and without branch retinal vein occlusion.
Next Document:  Comparison of two partial coherence interferometers for corneal pachymetry in high myopia and after ...