Document Detail

Increased responsiveness of sensory neurons in the saphenous nerve of the streptozotocin-diabetic rat.
MedLine Citation:
PMID:  1491258     Owner:  NLM     Status:  MEDLINE    
1. This study examined sensory neurons in the saphenous nerve of rats treated with streptozotocin to induce diabetes (STZ-D). Several physiological properties of sensory neurons were not significantly different in STZ-D compared with control (CON) rats, including percentage and rate of spontaneous activity seen in the whole nerve and mechanical and thermal thresholds of individual C-fibers. 2. The response of STZ-D and CON C-fibers to a sustained (1 min) mechanical stimulus of threshold force was similar. However, during the 5 min immediately after removal of this stimulus, there was a much greater afterdischarge in STZ-D rats (STZ-D: n = 35; 14.6 +/- 5.1 action potentials/5 min, mean +/- SE; CON: n = 34; 3.9 +/- 0.7 action potentials/5 min). The number of action potentials during a sustained (1 min) suprathreshold mechanical (445 g) stimulus was also significantly greater in the C-fibers from STZ-D rats (STZ-D: n = 44; 149.7 +/- 18.4 action potentials; CON: n = 45; 84.7 +/- 12.2 action potentials). The afterdischarge during the 5 min immediately after removal of the sustained suprathreshold stimulus was also greater in C-fibers from STZ-D rats (STZ-D: 38.7 +/- 13.1 action potentials/5 min; CON: 9.3 +/- 2.3 action potentials/5 min). 3. There was a significant difference between C-fibers from STZ-D and CON rats with respect to the distribution among certain sensory classes.(ABSTRACT TRUNCATED AT 250 WORDS)
S C Ahlgren; D M White; J D Levine
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurophysiology     Volume:  68     ISSN:  0022-3077     ISO Abbreviation:  J. Neurophysiol.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-03     Completed Date:  1993-03-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375404     Medline TA:  J Neurophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2077-85     Citation Subset:  IM; S    
Department of Anatomy, University of California, San Francisco 94143.
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MeSH Terms
Action Potentials / physiology
Diabetes Mellitus, Experimental / physiopathology*
Mechanoreceptors / physiology
Nerve Fibers / physiology
Nerve Fibers, Myelinated / physiology
Neural Conduction / physiology
Neurons, Afferent / physiology*
Physical Stimulation
Rats, Sprague-Dawley
Sensory Thresholds / physiology
Grant Support

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