Document Detail


Increased response of diastolic blood pressure to exercise in patients with coronary artery disease: an index of latent ventricular dysfunction?
MedLine Citation:
PMID:  8343317     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether an abnormal response of diastolic blood pressure during treadmill exercise stress testing correlated with the number of obstructed vessels and with left ventricular systolic function in patients with coronary artery disease. DESIGN: Diastolic blood pressure was measured invasively during exercise stress testing and coronary angiograms and left ventriculograms were obtained at rest in patients with coronary artery disease. The abnormal (> or = 15 mm Hg) diastolic blood pressure response was compared with the number of obstructed coronary arteries and with left ventricular systolic function. SETTING: Two tertiary referral centres. PATIENTS: 50 consecutive patients (mean age 57 years) with coronary artery disease. MAIN OUTCOME MEASURES: The increase in diastolic blood pressure during exercise and its correlation with the appearance and disappearance of ST segment deviation, resting left ventricular systolic function, and the number of obstructed coronary arteries. RESULTS: Group 1: 10 (20%) patients (three with one, four with two, and three with three vessel coronary artery disease) (mean (SD) age 54.7 (12) years) had an abnormal diastolic blood pressure response that appeared 1.2 (0.3) min before ST segment deviation and became normal 0.9 (0.3) min after the ST segment returned to normal. Group 2: 40 (80%) patients (12 with one, 16 with two, and 12 with three vessel coronary arteries disease) (aged 56.8 (8.2) years) had a normal diastolic blood pressure response to stress testing. The ejection fraction (46.3 (5)%) and cardiac index (2.6 (0.1) 1/min/m2) in group 1 were less than in group 2 (61.6 (4.2)% and 3.8 (0.3) 1/min/m2 respectively, p < or = 0.001). The end systolic volume was greater in group 1 than in group 2: 38.7 (0.7 ml/m2 v 28.2 (2.1) ml/m2, p < or = 0.001. CONCLUSION: In patients with coronary artery disease an abnormal increase in diastolic blood pressure during exercise stress testing correlated well with left ventricular systolic function at rest but not with the number of obstructed coronary arteries. The abnormal response of diastolic blood pressure probably reflects deterioration of myocardial function.
Authors:
I A Paraskevaidis; D T Kremastinos; A S Kassimatis; G K Karavolias; G D Kordosis; Z S Kyriakides; P K Toutouzas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  69     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-09-09     Completed Date:  1993-09-09     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  507-11     Citation Subset:  AIM; IM    
Affiliation:
Cardiac Department, Athens General Hospital, Athens University, Greece.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Coronary Disease / physiopathology*
Diastole / physiology
Exercise / physiology*
Exercise Test
Female
Humans
Male
Middle Aged
Ventricular Function, Left / physiology*
Comments/Corrections

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