Document Detail

Increased resistance of an interferon-resistant cell subline to the toxic effect of double-stranded RNA.
MedLine Citation:
PMID:  9826     Owner:  NLM     Status:  MEDLINE    
The toxicity of double-stranded (ds) f2-phage RNA for interferon-treated L cells and an interferon-resistant subline of L cells (CVS cells) was compared. The interferon-resistant subline proved to be about 20 times more resistant to ds RNA than the parent L cells. The degree of toxicity of ds RNA was dependent on the concentration of interferon to which the cells were exposed.
V Lackovic; L Borecký
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta virologica     Volume:  20     ISSN:  0001-723X     ISO Abbreviation:  Acta Virol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370401     Medline TA:  Acta Virol     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  347-8     Citation Subset:  IM    
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MeSH Terms
Cell Division / drug effects
Drug Resistance
Interferons / pharmacology
L Cells (Cell Line) / drug effects*
RNA, Viral / toxicity*
Reg. No./Substance:
0/RNA, Viral; 9008-11-1/Interferons

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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