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INCREASED RENAL SYMPATHETIC NERVE ACTIVITY LEADS TO HYPERTENSION AND RENAL DYSFUNCTION IN OFFSPRING FROM DIABETIC MOTHERS.
MedLine Citation:
PMID:  23136005     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The exposure of the fetus to a hyperglycemic environment promotes the development of hypertension and renal dysfunction in the offspring at adult age. We evaluated the role of renal nerves in the hypertension and renal changes seen in offspring of diabetic rats. Diabetes was induced in female Wistar rats (streptozotocin 60 mg/kg, ip) before mating. Male offspring from control and diabetic dams were studied at an age of 3 months. Systolic blood pressure measured by tail cuff was increased in offspring of diabetic dams (146 ± 1.6 mmHg, N=19, compared to 117 ± 1.4 mmHg, N=18, in controls). Renal function, baseline renal sympathetic nerve activity (rSNA) and arterial baroreceptor control of rSNA were analyzed in anesthetized animals. Glomerular filtration rate, fractional sodium excretion, and urine flow were significantly reduced in offspring of diabetic dams. Two weeks after renal denervation, blood pressure and renal function in offspring from diabetic dams were similar to control, suggesting that renal nerves contribute to sodium retention in offspring from diabetic dams. Moreover, basal rSNA was increased in offspring from diabetic dams, and baroreceptor control of rSNA was impaired, with blunted responses to infusion of nitroprusside and phenylephrine. Thus, data from this study indicate that in offspring from diabetic mother renal nerves has a clear role in the etiology of hypertension; however, other factors may also contribute to this condition.
Authors:
Aline Fernanda de Almeida Chaves Rodrigues; Ingrid Lauren Brites de Lima; Cássia Toledo Bergamaschi; Ruy R Campos; Aparecida Emiko Hirata; Guus H M Schoorlemmer; Guiomar Nascimento Gomes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-7
Journal Detail:
Title:  American journal of physiology. Renal physiology     Volume:  -     ISSN:  1522-1466     ISO Abbreviation:  Am. J. Physiol. Renal Physiol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901990     Medline TA:  Am J Physiol Renal Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1Universidade Federal de Sao Paulo.
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