| Increased renal net acid excretion in prematures below 1,600 g body weight compared with prematures and small-for-date newborns above 2,100 g on alimentation with a commercial preterm formula. | |
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MedLine Citation:
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PMID: 7948435 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 76 low birth weight infants with an actual body weight ranging from 1,210 to 2,540 g and fed a commercial preterm formula, urine samples were collected and blood acid base status was measured on day 38 (+/- 17, mean +/- SD) of life. Infants with an actual body weight below 1,600 g demonstrated a higher daily weight gain (22 +/- 3 vs. 14 +/- 5 g/kg/day), lower blood pCO2 (35.4 +/- 5.0 vs. 38.9 +/- 3.8 mm Hg), lower urine pH (5.8 +/- 0.5 vs. 6.5 +/- 0.3), higher renal net acid (1.86 +/- 0.38 vs. 1.28 +/- 0.55 mmol/kg/day) and higher phosphorus excretion (0.67 vs. 0.52 mmol/kg/day) than infants with an actual body weight above 2,100 g. Urinary ionogram data of these 2 groups of infants show that the increased renal net acid excretion of the smaller prematures is the result of a lower urinary excretion of sodium, potassium and chloride, due to a higher daily weight gain, probably a higher retention of these minerals, and a higher urinary phosphorus excretion probably due to an age-specific lower intestinal calcium absorption, and therefore a lower rate of calcium and phosphorus retention. Considering the low renal capacity for hydrogen ion excretion, very low birth weight infants still run a considerable risk for disturbances of acid base metabolism due to the high mean level of net acid excretion in nutrition with preterm formulas and an additional age-specific augmentation of renal acid load. |
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Authors:
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H Kalhoff; B Wiese; C Kunz; L Diekmann; G J Stock; F Manz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 66 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-02 Completed Date: 1994-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 10-5 Citation Subset: IM |
Affiliation:
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Children's Hospital, Dortmund, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium* Birth Weight* Calcium / urine Creatinine / urine Female Humans Hydrogen-Ion Concentration Infant, Newborn Infant, Premature / metabolism* Infant, Small for Gestational Age / metabolism* Kidney / metabolism* Male Phosphorus / urine Potassium / urine Sodium / urine Urine |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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