Document Detail


Increased renal net acid excretion in prematures below 1,600 g body weight compared with prematures and small-for-date newborns above 2,100 g on alimentation with a commercial preterm formula.
MedLine Citation:
PMID:  7948435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 76 low birth weight infants with an actual body weight ranging from 1,210 to 2,540 g and fed a commercial preterm formula, urine samples were collected and blood acid base status was measured on day 38 (+/- 17, mean +/- SD) of life. Infants with an actual body weight below 1,600 g demonstrated a higher daily weight gain (22 +/- 3 vs. 14 +/- 5 g/kg/day), lower blood pCO2 (35.4 +/- 5.0 vs. 38.9 +/- 3.8 mm Hg), lower urine pH (5.8 +/- 0.5 vs. 6.5 +/- 0.3), higher renal net acid (1.86 +/- 0.38 vs. 1.28 +/- 0.55 mmol/kg/day) and higher phosphorus excretion (0.67 vs. 0.52 mmol/kg/day) than infants with an actual body weight above 2,100 g. Urinary ionogram data of these 2 groups of infants show that the increased renal net acid excretion of the smaller prematures is the result of a lower urinary excretion of sodium, potassium and chloride, due to a higher daily weight gain, probably a higher retention of these minerals, and a higher urinary phosphorus excretion probably due to an age-specific lower intestinal calcium absorption, and therefore a lower rate of calcium and phosphorus retention. Considering the low renal capacity for hydrogen ion excretion, very low birth weight infants still run a considerable risk for disturbances of acid base metabolism due to the high mean level of net acid excretion in nutrition with preterm formulas and an additional age-specific augmentation of renal acid load.
Authors:
H Kalhoff; B Wiese; C Kunz; L Diekmann; G J Stock; F Manz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biology of the neonate     Volume:  66     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  10-5     Citation Subset:  IM    
Affiliation:
Children's Hospital, Dortmund, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium*
Birth Weight*
Calcium / urine
Creatinine / urine
Female
Humans
Hydrogen-Ion Concentration
Infant, Newborn
Infant, Premature / metabolism*
Infant, Small for Gestational Age / metabolism*
Kidney / metabolism*
Male
Phosphorus / urine
Potassium / urine
Sodium / urine
Urine
Chemical
Reg. No./Substance:
60-27-5/Creatinine; 7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; 7723-14-0/Phosphorus

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