| Increased renal dopamine and acute renal adaptation to a high-phosphate diet. | |
| | |
MedLine Citation:
|
PMID: 21325500 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The current experiments explore the role of dopamine in facilitating the acute increase in renal phosphate excretion in response to a high-phosphate diet. Compared with a low-phosphate (0.1%) diet for 24 h, mice fed a high-phosphate (1.2%) diet had significantly higher rates of phosphate excretion in the urine associated with a two- to threefold increase in the dopamine content of the kidney and in the urinary excretion of dopamine. Animals fed a high-phosphate diet had a significant increase in the abundance and activity of renal DOPA (l-dihydroxyphenylalanine) decarboxylase and significant reductions in renalase, monoamine oxidase A, and monoamine oxidase B. The activity of protein kinase A and protein kinase C, markers of activation of renal dopamine receptors, were significantly higher in animals fed a high-phosphate vs. a low-phosphate diet. Treatment of rats with carbidopa, an inhibitor of DOPA decarboxylase, impaired adaptation to a high-phosphate diet. These experiments indicate that the rapid adaptation to a high-phosphate diet involves alterations in key enzymes involved in dopamine synthesis and degradation, resulting in increased renal dopamine content and activation of the signaling cascade used by dopamine to inhibit the renal tubular reabsorption of phosphate. |
| | |
Authors:
|
Edward J Weinman; Rajatsubhra Biswas; Deborah Steplock; Peili Wang; Yuen-Sum Lau; Gary V Desir; Shirish Shenolikar |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-02-16 |
Journal Detail:
|
Title: American journal of physiology. Renal physiology Volume: 300 ISSN: 1522-1466 ISO Abbreviation: Am. J. Physiol. Renal Physiol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-05 Completed Date: 2011-07-01 Revised Date: 2012-05-01 |
Medline Journal Info:
|
Nlm Unique ID: 100901990 Medline TA: Am J Physiol Renal Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: F1123-9 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Maryland School of Medicine, Baltimore, 21201, USA. eweinman1440@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adaptation, Physiological Analysis of Variance Animals Carbidopa / pharmacology Cyclic AMP-Dependent Protein Kinases / metabolism Dopa Decarboxylase / antagonists & inhibitors, metabolism Dopamine / metabolism*, urine Enzyme Inhibitors / pharmacology Kidney / drug effects, metabolism* Male Mice Mice, Inbred C57BL Monoamine Oxidase / metabolism Phosphorus, Dietary / administration & dosage, metabolism*, urine Protein Kinase C / metabolism Rats Rats, Sprague-Dawley Signal Transduction Time Factors Up-Regulation |
| Grant Support | |
ID/Acronym/Agency:
|
DK081037/DK/NIDDK NIH HHS; DK086402/DK/NIDDK NIH HHS; DK086465/DK/NIDDK NIH HHS; DK55881/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Enzyme Inhibitors; 0/Phosphorus, Dietary; 38821-49-7/Carbidopa; EC 1.4.3.4/Monoamine Oxidase; EC 1.4.3.4./renalase; EC 2.7.11.11/Cyclic AMP-Dependent Protein Kinases; EC 2.7.11.13/Protein Kinase C; EC 4.1.1.-/Dopa Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitiv...
Next Document: Role for reelin in neurotransmitter release.