| Increased regional cerebral perfusion by 99mTc hexamethyl propylene amine oxime single photon emission computed tomography in post-traumatic stress disorder. | |
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MedLine Citation:
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PMID: 10870367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Because of the treatment resistance and chronic affective lability of many post-traumatic stress disorder (PTSD) patients and the hypothesized association of these behaviors with temporal and limbic structures, a study was conducted to determine whether these patients would exhibit alterations in regional cerebral perfusion in the temporal and limbic regions compared with age-matched normal volunteers at rest. METHOD: We studied 17 patients using 99mTc hexamethyl propylene amine oxime single photon emission computed tomography. Seven of the patients were on a selective serotonin reuptake inhibitor, five were on a tricyclic antidepressant, and five were on no medication at the time of the study. Patients were compared with eight age-matched normal controls. RESULTS: All PTSD patients showed a relative increase in regional cerebral perfusion in the anterior and posterior cingulate regions bilaterally, the right temporal and parietal regions, the right caudate/putamen region, and the left orbital and hippocampal regions compared with the control group. When the group of PTSD patients who were free of medication were compared with the control group, increased regional cerebral perfusion was found in the right and left caudate/putamen regions and the right orbital and anterior cingulate cortex bilaterally. CONCLUSIONS: PTSD is associated with increased regional blood flow in limbic areas and the right temporal and parietal cortex compared with age-matched normal volunteers. |
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Authors:
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N Sachinvala; A Kling; S Suffin; R Lake; M Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Military medicine Volume: 165 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2000 Jun |
Date Detail:
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Created Date: 2000-07-27 Completed Date: 2000-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 473-9 Citation Subset: IM |
Affiliation:
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Sepulveda Veterans Affairs Medical Center, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Brain / blood supply Case-Control Studies Humans Limbic System / blood supply*, radionuclide imaging Male Mental Disorders / physiopathology, radionuclide imaging Middle Aged Statistics, Nonparametric Stress Disorders, Post-Traumatic / physiopathology*, radionuclide imaging Technetium Tc 99m Exametazime / diagnostic use Temporal Lobe / blood supply*, radionuclide imaging Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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100504-35-6/Technetium Tc 99m Exametazime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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