| Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin. | |
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MedLine Citation:
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PMID: 8302459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of recombinant human erythropoietin (rHuEpo) for the treatment of renal anaemia is well established. To assess the effect of rHuEpo treatment on physical performance we evaluated physical working capacity, oxygen uptake and red cell 2,3-diphosphoglycerate (DPG) values at rest and during and after exercise on a bicycle spiroergometer in eight chronically haemodialysed patients. Follow-up examination was carried out after a mean of 14 weeks (range 9-19 weeks), when mean haemoglobin had increased from 7.8 to a stable value of 13.0 g/dl in response to rHuEpo treatment (P < 0.001). Physical working capacity and oxygen uptake at the anaerobic threshold (4 mmol/l blood lactate concentration) increased from 68 +/- 12 to 80 +/- 16 watts and 0.95 +/- 0.14 to 1.10 +/- 0.20 l/min, respectively (P < 0.01). DPG, which determines oxygen affinity to haemoglobin in red cells, increased by 13% from 13.7 +/- 1.5 to 15.5 +/- 2.2 mumol/g Hb (P < 0.05). With maximal exercise mean DPG values significantly decreased to a much lower level without rHuEpo treatment than after correction of anaemia. Therefore rHuEpo treatment results both in better oxygen transport capacity and reduced intraerythrocytic oxygen affinity, which is followed by improved oxygen delivery to tissues per unit of haemoglobin. These effects may explain the improvement of exercise capacity observed in dialysis patients after rHuEpo treatment. |
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Authors:
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J H Horina; G Schwaberger; H Brussee; G Sauseng-Fellegger; H Holzer; G J Krejs |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 8 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1993 |
Date Detail:
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Created Date: 1994-03-08 Completed Date: 1994-03-08 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1219-22 Citation Subset: IM |
Affiliation:
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Department of Medicine, Karl Franzens University, Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2,3-Diphosphoglycerate Adult Anemia / drug therapy, metabolism Diphosphoglyceric Acids / blood* Erythrocytes / chemistry* Erythropoietin / pharmacology*, therapeutic use Female Humans Male Middle Aged Oxygen / metabolism Physical Exertion Recombinant Proteins / pharmacology Renal Dialysis* |
| Chemical | |
Reg. No./Substance:
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0/Diphosphoglyceric Acids; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 138-81-8/2,3-Diphosphoglycerate; 7782-44-7/Oxygen |
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