Document Detail


Increased red cell 2,3-diphosphoglycerate levels in haemodialysis patients treated with erythropoietin.
MedLine Citation:
PMID:  8302459     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of recombinant human erythropoietin (rHuEpo) for the treatment of renal anaemia is well established. To assess the effect of rHuEpo treatment on physical performance we evaluated physical working capacity, oxygen uptake and red cell 2,3-diphosphoglycerate (DPG) values at rest and during and after exercise on a bicycle spiroergometer in eight chronically haemodialysed patients. Follow-up examination was carried out after a mean of 14 weeks (range 9-19 weeks), when mean haemoglobin had increased from 7.8 to a stable value of 13.0 g/dl in response to rHuEpo treatment (P < 0.001). Physical working capacity and oxygen uptake at the anaerobic threshold (4 mmol/l blood lactate concentration) increased from 68 +/- 12 to 80 +/- 16 watts and 0.95 +/- 0.14 to 1.10 +/- 0.20 l/min, respectively (P < 0.01). DPG, which determines oxygen affinity to haemoglobin in red cells, increased by 13% from 13.7 +/- 1.5 to 15.5 +/- 2.2 mumol/g Hb (P < 0.05). With maximal exercise mean DPG values significantly decreased to a much lower level without rHuEpo treatment than after correction of anaemia. Therefore rHuEpo treatment results both in better oxygen transport capacity and reduced intraerythrocytic oxygen affinity, which is followed by improved oxygen delivery to tissues per unit of haemoglobin. These effects may explain the improvement of exercise capacity observed in dialysis patients after rHuEpo treatment.
Authors:
J H Horina; G Schwaberger; H Brussee; G Sauseng-Fellegger; H Holzer; G J Krejs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association     Volume:  8     ISSN:  0931-0509     ISO Abbreviation:  Nephrol. Dial. Transplant.     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8706402     Medline TA:  Nephrol Dial Transplant     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1219-22     Citation Subset:  IM    
Affiliation:
Department of Medicine, Karl Franzens University, Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
2,3-Diphosphoglycerate
Adult
Anemia / drug therapy,  metabolism
Diphosphoglyceric Acids / blood*
Erythrocytes / chemistry*
Erythropoietin / pharmacology*,  therapeutic use
Female
Humans
Male
Middle Aged
Oxygen / metabolism
Physical Exertion
Recombinant Proteins / pharmacology
Renal Dialysis*
Chemical
Reg. No./Substance:
0/Diphosphoglyceric Acids; 0/Recombinant Proteins; 11096-26-7/Erythropoietin; 138-81-8/2,3-Diphosphoglycerate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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