Document Detail

Increased recurrence of preterm delivery with early cessation of 17-alpha-hydroxyprogesterone caproate.
MedLine Citation:
PMID:  17346529     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to identify the effect of early cessation of 17-alpha-hydroxyprogesterone caproate (17P) on the incidence of spontaneous recurrent preterm delivery (PTD). STUDY DESIGN: Retrospective analysis of data from women who were enrolled for outpatient 17P administration between January 2004 and May 2006 included women with previous PTD and current singleton pregnancy who were beginning weekly 17P injections (250 mg intramuscularly) at 16-20.9 weeks. The study group was comprised of patients who were electively terminating 17P at <32.0 weeks and who delivered >10 days from the last injection. The control group consisted of patients who received weekly 17P injections until PTD or 36.9 weeks of gestation. The primary study outcome was the rate of recurrent spontaneous PTD. RESULTS: Study group patients were significantly more likely to have spontaneous recurrent PTD at <37 weeks of gestation (48.1% vs 33.3%; P = .011), at <35 weeks of gestation (30.9% vs 14.0%; P < .001), and at <32 weeks of gestation (16.0% vs 7.0%; P = .020). CONCLUSION: Early cessation of 17P treatment is associated with an increased risk for spontaneous recurrent PTD.
Andrei Rebarber; Lauren A Ferrara; Maryellen L Hanley; Niki B Istwan; Debbie J Rhea; Gary J Stanziano; Daniel H Saltzman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  196     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-09     Completed Date:  2007-05-03     Revised Date:  2008-02-19    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  224.e1-4     Citation Subset:  AIM; IM    
Department of Maternal Fetal Medicine, Mount Sinai School of Medicine, New York, NY, USA.
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MeSH Terms
Abortion, Habitual / epidemiology*
Hydroxyprogesterones / administration & dosage*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Premature Birth / prevention & control*
Retrospective Studies
Reg. No./Substance:
0/Hydroxyprogesterones; 630-56-8/17-alpha-hydroxy-progesterone caproate
Comment In:
Am J Obstet Gynecol. 2008 Feb;198(2):244; author reply 244-5   [PMID:  18226639 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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