| Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. | |
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MedLine Citation:
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PMID: 22622349 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. |
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Authors:
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Nina Sanapareddy; Ryan M Legge; Biljana Jovov; Amber McCoy; Lauren Burcal; Felix Araujo-Perez; Thomas A Randall; Joseph Galanko; Andrew Benson; Robert S Sandler; John F Rawls; Zaid Abdo; Anthony A Fodor; Temitope O Keku |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-24 |
Journal Detail:
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Title: The ISME journal Volume: - ISSN: 1751-7370 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101301086 Medline TA: ISME J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Bioinformatics and Genomics, University of North Carolina, Charlotte, NC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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