Document Detail


Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.
MedLine Citation:
PMID:  22622349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.
Authors:
Nina Sanapareddy; Ryan M Legge; Biljana Jovov; Amber McCoy; Lauren Burcal; Felix Araujo-Perez; Thomas A Randall; Joseph Galanko; Andrew Benson; Robert S Sandler; John F Rawls; Zaid Abdo; Anthony A Fodor; Temitope O Keku
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-05-24
Journal Detail:
Title:  The ISME journal     Volume:  6     ISSN:  1751-7370     ISO Abbreviation:  ISME J     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-05-02     Revised Date:  2014-04-14    
Medline Journal Info:
Nlm Unique ID:  101301086     Medline TA:  ISME J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1858-68     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoma / microbiology*,  pathology
Bacteria / classification,  genetics
Biopsy
Case-Control Studies
Colorectal Neoplasms / microbiology*,  pathology
DNA, Bacterial / genetics
Female
Humans
Male
Metagenome*
Middle Aged
RNA, Ribosomal, 16S / genetics
Rectum / microbiology*,  pathology
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
K01 DK 073695/DK/NIDDK NIH HHS; P30 DK034987/DK/NIDDK NIH HHS; P30 ES010126/ES/NIEHS NIH HHS; P30DK034987/DK/NIDDK NIH HHS; P50 CA106991/CA/NCI NIH HHS; P50 CA106991/CA/NCI NIH HHS; R01 CA044684/CA/NCI NIH HHS; R01 CA136887/CA/NCI NIH HHS; R01 CA136887/CA/NCI NIH HHS; R01 CA44684/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Bacterial; 0/RNA, Ribosomal, 16S
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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