| Increased lactulose/rhamnose ratio during fluid load is caused by increased urinary lactulose excretion. | |
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MedLine Citation:
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PMID: 10644565 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noninvasive assessment of intestinal permeability in vivo is based on the measurement of urinary excretion of orally administered sugar probes. It is expressed as a ratio, usually lactulose/rhamnose or 3-O-methyl-D-glucose (3-OMG)/rhamnose. In both endotoxemic and control rats that were receiving fluid, we observed an increase in the recovery of lactulose and 3-OMG but not rhamnose in both groups, suggesting an enhancement of intestinal permeability. In the measurement of intestinal permeability, all pre- and postmucosal factors are considered equal for all sugars. We hypothesized that postmucosal factors and not changes in intestinal permeability caused the increased urinary lactulose and 3-OMG recoveries observed during fluid loading. Therefore, the effects of fluid loading on urinary excretion of the sugar probes were studied in healthy rats receiving the sugars intravenously. After intravenous injection, fluid loading increased urinary lactulose recovery threefold but not that of 3-OMG and rhamnose. In conclusion, fluid loading increases the lactulose/rhamnose ratio independent of changes in intestinal permeability. The 3-OMG/rhamnose ratio is not influenced by fluid loading. |
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Authors:
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M M Hallemeesch; W H Lamers; P B Soeters; N E Deutz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of physiology. Gastrointestinal and liver physiology Volume: 278 ISSN: 0193-1857 ISO Abbreviation: Am. J. Physiol. Gastrointest. Liver Physiol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-06-16 Completed Date: 2000-06-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901227 Medline TA: Am J Physiol Gastrointest Liver Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: G83-8 Citation Subset: IM |
Affiliation:
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Department of Surgery, Maastricht University, 6200 MD Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-O-Methylglucose
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administration & dosage,
urine Animals Endotoxemia / metabolism, urine Injections, Intravenous Intestinal Mucosa / metabolism Intestines / metabolism Lactulose / administration & dosage, metabolism*, urine Male Permeability Rats Rats, Wistar Reference Values Rhamnose / administration & dosage, metabolism*, urine Sodium Chloride / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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10485-94-6/Rhamnose; 146-72-5/3-O-Methylglucose; 4618-18-2/Lactulose; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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