Document Detail


Increased rates of hepatic cholesterogenesis and fatty acid synthesis in septic rats in vivo: evidence for the possible involvement of insulin.
MedLine Citation:
PMID:  2647366     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Sepsis induced by caecal ligation and puncture increased the rates of hepatic cholesterogenesis and fatty acid synthesis in vivo compared with sham-operated rats. These changes were accompanied by higher concentrations of lactate and pyruvate in blood and liver and an increase in plasma insulin. 2. The total activity of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (EC 1.1.1.88) in liver was increased by sepsis, but there was no significant change in the expressed activity. Short-term insulin deficiency (induced by mannoheptulose or streptozotocin) decreased the rates of cholesterogenesis and fatty acid synthesis in livers of septic rats but did not alter the expressed/total activity of HMG-CoA reductase. 3. It is concluded that the increased rate of hepatic cholesterogenesis in septic rats is in part a result of the higher plasma insulin, the hormone acting to maintain the total activity of HMG-CoA reductase and to stimulate a step before the formation of HMG-CoA. 4. These changes may contribute to the hypertriacylglycerolaemia associated with sepsis.
Authors:
P R de Vasconcelos; M G Kettlewell; G F Gibbons; D H Williamson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  76     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-04-26     Completed Date:  1989-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Affiliation:
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Infections / metabolism*
Cholesterol / biosynthesis*
Diabetes Mellitus, Experimental / metabolism
Fatty Acids / biosynthesis*
Hydroxymethylglutaryl CoA Reductases / metabolism
Insulin / physiology
Liver / metabolism*
Male
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
0/Fatty Acids; 11061-68-0/Insulin; 57-88-5/Cholesterol; EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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