Document Detail

Increased radioresistance of cells in cultured multicell spheroids. II. Kinetic and cytogenetic studies.
MedLine Citation:
PMID:  6867266     Owner:  NLM     Status:  MEDLINE    
Using the Chinese hamster cell line B14 FAF28, several specific properties of the contact effect (CE) of radiation action in spheroids were investigated. CE was found to "protect" the spheroid cells against several types of radiation-induced cytogenetic misfunctions such as blockage in S and G2+M-phase, mutagenesis, and chromosome damage. However, repair of DNA strand-breaks was the same in monolayers and spheroids. Furthermore, CE is a property of the single cell and does not depend on the proliferative status (cycling or non-cycling) of the cells. We conclude that CE is the result of a physiological modification of the cells occurring during growth in the three-dimensional spheroid matrix and requiring metabolic cooperation and cyclic AMP for its induction.
G Hinz; H Dertinger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  21     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1983  
Date Detail:
Created Date:  1983-08-17     Completed Date:  1983-08-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  255-64     Citation Subset:  IM    
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MeSH Terms
Cell Aggregation / radiation effects*
Cell Communication / radiation effects*
Cell Cycle / radiation effects*
Cell Line
Cell Survival / radiation effects
Chromosomes / radiation effects
DNA Repair
Flow Cytometry

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