Document Detail


Increased radioresistance of cells in cultured multicell spheroids. II. Kinetic and cytogenetic studies.
MedLine Citation:
PMID:  6867266     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using the Chinese hamster cell line B14 FAF28, several specific properties of the contact effect (CE) of radiation action in spheroids were investigated. CE was found to "protect" the spheroid cells against several types of radiation-induced cytogenetic misfunctions such as blockage in S and G2+M-phase, mutagenesis, and chromosome damage. However, repair of DNA strand-breaks was the same in monolayers and spheroids. Furthermore, CE is a property of the single cell and does not depend on the proliferative status (cycling or non-cycling) of the cells. We conclude that CE is the result of a physiological modification of the cells occurring during growth in the three-dimensional spheroid matrix and requiring metabolic cooperation and cyclic AMP for its induction.
Authors:
G Hinz; H Dertinger
Related Documents :
9952296 - The radiation-induced s-phase checkpoint is independent of cdkn1a.
12120006 - Treatment with 5-fluorouracil enhances radiosensitivity of the human pancreatic cancer ...
15913396 - Hypoxia-induced bax overexpression and radiation killing of hypoxic glioblastoma cells.
20119866 - Ac480, formerly bms-599626, a pan her inhibitor, enhances radiosensitivity and radiores...
8168106 - Nickel-induced transformation of human cells causes loss of the phosphorylation of the ...
9696786 - Importance of glutathione for growth and survival of escherichia coli cells: detoxifica...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiation and environmental biophysics     Volume:  21     ISSN:  0301-634X     ISO Abbreviation:  Radiat Environ Biophys     Publication Date:  1983  
Date Detail:
Created Date:  1983-08-17     Completed Date:  1983-08-17     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0415677     Medline TA:  Radiat Environ Biophys     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  255-64     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Aggregation / radiation effects*
Cell Communication / radiation effects*
Cell Cycle / radiation effects*
Cell Line
Cell Survival / radiation effects
Chromosomes / radiation effects
Cricetinae
Cricetulus
DNA Repair
Flow Cytometry
Kinetics
Mutation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Response of mouse small intestine to fractionated doses of pions.
Next Document:  RBE of spleen CFU-S to low dose rate Cf-252 neutron or photon radiation.