Document Detail

Increased pulse pressure is associated with left atrial enlargement in resistant hypertensive patients.
MedLine Citation:
PMID:  23305454     Owner:  NLM     Status:  In-Data-Review    
Abstract Resistant hypertension (RH) is frequently associated with a high prevalence of target organ damage, which impairs the prognosis of these patients. Considering cardiac alterations in RH, most attention has been devoted to left ventricular hypertrophy (LVH), but data concerning left atrial enlargement (LAE) is less known. This cross-sectional study assessed the factors associated with LAE, with special focus on blood pressure (BP) estimates obtained by ambulatory blood pressure monitoring (ABPM), in 250 patients with RH, aged 64 ± 11 years. LAE and LVH were observed in 10.0% (95% CI 6.3-13.7) and 57.1% (95% CI 50.8-63.5) of patients, respectively. Compared with patients with normal atrium size, those exhibiting LAE were older, more frequently women, had elevated pulse pressure (PP) measured both at the office and by ABPM, and showed higher prevalence of LVH (83% vs 54%; p = 0.016). In a logistic regression analysis, adjusting for age, gender, body mass index, left ventricular mass index and BP pressure estimates, night-time PP was independently associated with LAE (OR for 5 mmHg = 1.28, 95% CI 1.24-1.32; p = 0.001). In conclusion, besides classical determinants of LAE, such as age and LVH, an elevated night-time PP was independently associated with LAE in patients with RH.
Pedro Armario; Anna Oliveras; Raquel Hernández-Del-Rey; Carmen Suárez; Nieves Martell; Luis M Ruilope; Alejandro De La Sierra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  22     ISSN:  1651-1999     ISO Abbreviation:  Blood Press.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2013-01-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-44     Citation Subset:  IM    
Hypertension and Vascular Risk Unit, Department of Internal Medicine, Hospital General de L'Hospitalet, University of Barcelona , Spain.
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