Document Detail

Increased pulse pressure amplification in treated hypertensive subjects with metabolic syndrome.
MedLine Citation:
PMID:  17261456     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Brachial pulse pressure (PP) is physiologically higher than central PP. This PP amplification, which protects the heart from increased afterload, is related to the progressive increase of arterial stiffness along the vascular tree and subsequent changes in pressure wave reflections. The PP amplification increases with high heart rate (HR), which is observed in subjects with metabolic syndrome (MS). The objective of this study was to investigate whether PP amplification is affected by MS and is related to cardiovascular (CV) risk. METHODS: In 613 subjects treated for hypertension (41% with MS) pulse wave analysis was used to investigate carotid blood pressure (BP), pressure wave reflections from carotid augmentation index (AI), and arterial stiffness from aortic pulse wave velocity (PWV). The CV risk was estimated from standard Framingham equations. RESULTS: Pulse pressure amplification, HR, and PWV, but not AI, were increased in subjects with MS compared to control subjects without MS with the same age, gender, and mean arterial pressure. The difference in PP amplification between the two groups disappeared after adjustment for both HR and PWV. The AI was the main predictor of PP amplification, representing 28% and 19% of its total variance in subjects without and with MS, respectively. The CV risk for coronary, but not for cerebral, mortality was related to PP amplification. CONCLUSIONS: Although PWV is increased in treated hypertensive subjects with MS, compared to control, PP amplification is increased due to the effect of increased HR and attenuated pressure wave reflections. The observed relation of increased PP amplification with organ-specific CV risk needs further investigation.
Athanase D Protogerou; Jacques Blacher; Myron Mavrikakis; John Lekakis; Michel E Safar
Related Documents :
12817176 - Use of arterial transfer functions for the derivation of aortic waveform characteristics.
20489686 - Arterial stiffness and wave reflections in marathon runners.
6224026 - The relationship of the baseline ecg to blood pressure change.
1833966 - Arterial distensibility and left ventricular hypertrophy in patients with sustained ess...
7599806 - Renal hemodynamic and functional effect of peep ventilation in human renal transplantat...
15298876 - Comparison of the lma-proseal and lma-classic in children.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of hypertension     Volume:  20     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-30     Completed Date:  2007-05-07     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure*
Blood Pressure Determination*
Brachial Artery
Cardiovascular Diseases / diagnosis*,  etiology
Carotid Arteries
Heart Rate
Hypertension / complications*,  drug therapy
Metabolic Syndrome X / complications*
Middle Aged
Pulsatile Flow

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electronic monitoring of adherence as a tool to improve blood pressure control. A randomized control...
Next Document:  Longitudinal analysis of blood pressure trends and prognosis in isolated systolic hypertension in el...