| Increased pulmonary response to inhaled endotoxin in lactating rats. | |
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MedLine Citation:
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PMID: 8484616 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An important aspect of risk assessment is identification of subpopulations particularly susceptible to the effects of inhaled pollutants. The present study examined whether female rats were more sensitive during lactation to the acute pulmonary injury produced by inhaled endotoxin. Lactating and age-matched virgin female rats were exposed to aerosols of saline or endotoxin for 3 h and lavaged at 24 h after exposure. No significant differences in lactate dehydrogenase, beta-glucuronidase, total protein, and total cell and PMN counts were observed between virgin and lactating rats after exposure to saline. Each marker of pulmonary injury except beta-glucuronidase was 1.5- to 3-fold greater in lactating than in virgin female rats exposed to 29.6 micrograms/m3 endotoxin. PMNs (6-fold), total cell counts, and protein were also significantly increased (p < 0.05) in lactating rats exposed to 1.3 micrograms/m3 endotoxin, a concentration reported to occur in a number of agricultural settings. These results demonstrate that the physiologic state of lactation is associated with an increased sensitivity to the acute pulmonary injury produced by inhaled endotoxin and are consistent with previous work demonstrating a similar increased sensitivity to ozone exposure. The possibility of a similar pattern of enhanced response in analogous groups of humans merits examination. |
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Authors:
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T Gordon; P A Weideman; A F Gunnison |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American review of respiratory disease Volume: 147 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-06-03 Completed Date: 1993-06-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1100-4 Citation Subset: AIM; IM |
Affiliation:
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Institute of Environmental Medicine, New York University Medical Center, Tuxedo 10987. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Air Pollutants / toxicity Animals Bronchoalveolar Lavage Fluid / chemistry, pathology Cell Count Endotoxins / administration & dosage*, toxicity Female Glucuronidase / metabolism L-Lactate Dehydrogenase / metabolism Lactation* Lung / metabolism, pathology* Neutrophils / pathology Proteins / metabolism Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
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ES-00260/ES/NIEHS NIH HHS; ES-02429/ES/NIEHS NIH HHS; ES-04947/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants; 0/Endotoxins; 0/Proteins; 67924-63-4/endotoxin, Escherichia coli; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 3.2.1.31/Glucuronidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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