| Increased proteolysis in chromatin of terminally differentiated and quiescent cells. | |
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MedLine Citation:
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PMID: 6370706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endogenous proteolysis in chromatin of terminally differentiated, quiescent, and actively proliferating cells was studied by measuring the released acid-soluble radioactivity of [3H]tryptophan-prelabelled nuclear proteins, and by following the specific quantitative and qualitative changes in electrophoregrams of chromosomal proteins. The experiments suggest that the chromatin of differentiated mouse kidney and liver cells, as well as chromatin from Friend cells induced to commit terminal differentiation, exhibit increased proteolysis in comparison with that of chromatin isolated from actively proliferating cells. Enhanced proteolysis was found also for the slowly renewing and quiescent cells from adult mice. The control experiments designated to discriminate between the two possible alternatives explaining the difference--increased activity of the proteolytic enzymes associated with chromatin, or increased susceptibility of the chromosomal proteins to proteases--supported the latter alternative. |
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Authors:
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L P Djondjurov; N Y Yancheva; E C Ivanova; K Christov |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Experimental cell research Volume: 152 ISSN: 0014-4827 ISO Abbreviation: Exp. Cell Res. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-06-05 Completed Date: 1984-06-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 134-47 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow Cells Cell Differentiation* Cell Division* Chromatin / metabolism* Chromosomal Proteins, Non-Histone / metabolism Histones / metabolism Interphase* Kidney / cytology Leukemia, Erythroblastic, Acute Liver / cytology Mice Mice, Inbred C57BL Peptide Hydrolases / metabolism Spleen / cytology |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Chromosomal Proteins, Non-Histone; 0/Histones; EC 3.4.-/Peptide Hydrolases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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