| Increased protein expression of matrix metalloproteinases -1, -3, and -9 and TIMP-1 in patients with gluten-sensitive enteropathy. | |
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MedLine Citation:
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PMID: 16964549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gluten-sensitive enteropathy is characterized by small intestinal damage. The pathogenic mechanisms involved are not precisely understood. There is recent interest in the possibility that matrix metalloproteinases might play a pathogenic role. Using immunohistochemistry technique, we examined the protein expression of matrix metalloproteinases-1, -3, and -9 and the tissue inhibitor metalloproteinase-1 in duodenal biopsies from 30 patients with celiac disease and dermatitis herpetiformis. We demonstrated that the percentage of cells expressing these enzymes and their inhibitor in all patients was significantly greater than in the normal controls (P < 0.0001). This was evident even in patients with a minimal lesion but was most marked in patients with severe damage, mirroring the degree of inflammation in the small intestinal tissue. The increased expression of these enzymes and their inhibitor in the duodenal mucosa of patients with gluten-sensitive enteropathy suggests a role for these enzymes in the tissue remodeling which is a feature of these disorders. |
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Authors:
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Bashir M Mohamed; Conleth Feighery; Jacinta Kelly; Christian Coates; Una O'Shea; Louise Barnes; Mohamed Abuzakouk |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 51 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2007-01-04 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 1862-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Immunology, St. James's Hospital, Trinity College and Dublin Molecular Medicine Center, Dublin, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Celiac Disease / enzymology*, pathology, therapy Dermatitis Herpetiformis / enzymology*, pathology Duodenum / enzymology* Female Humans Intestinal Mucosa / enzymology Male Matrix Metalloproteinases, Secreted / metabolism* Middle Aged Severity of Illness Index Tissue Inhibitor of Metalloproteinase-1 / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Tissue Inhibitor of Metalloproteinase-1; EC 3.4.24.-/Matrix Metalloproteinases, Secreted |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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