Document Detail


Increased prevalence of significant coronary artery calcification in patients with diabetes.
MedLine Citation:
PMID:  11213888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Coronary artery disease is the major cause of morbidity and mortality in patients with diabetes. Detection of coronary artery disease before the first myocardial infarction and before anginal symptoms will allow for strategies designed to reduce the cardiovascular event rate in this group of patients. Electron beam-computed tomography (EBCT) is a noninvasive technology for evaluating the extent of coronary artery atherosclerosis that relies on the detection of coronary artery calcium (CAC). We used EBCT to detect significant coronary artery atherosclerosis in diabetic patients without symptoms of heart disease. RESEARCH DESIGN AND METHODS: We used EBCT to evaluate calcium in the coronary arteries of 139 consecutive diabetic patients scanned over a 20-month period. The CAC scores in this group were compared with a randomly selected nondiabetic control group and a control group that was selected to match a number of established cardiovascular risk factors. RESULTS: Patients with diabetes had a significant increase in the prevalence of CAC scores > or =400 (25.9%) compared with the randomly selected (7.2%) and matched (14.4%) nondiabetic control groups. Scores in this range have been reported to be highly predictive for abnormal stress myocardial perfusion tomography and subsequent coronary events. CONCLUSIONS: Our results, therefore, indicate a substantial prevalence of significant coronary artery disease in an asymptomatic diabetic patient population compared with nondiabetic control subjects. They also suggest that EBCT may be a useful approach for selecting a group of diabetic subjects who would benefit most from additional evaluation for subclinical coronary artery disease.
Authors:
S Schurgin; S Rich; T Mazzone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetes care     Volume:  24     ISSN:  0149-5992     ISO Abbreviation:  Diabetes Care     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-02-13     Completed Date:  2001-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7805975     Medline TA:  Diabetes Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  335-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Rush Medical College, Chicago, Illinois, USA.
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MeSH Terms
Descriptor/Qualifier:
Calcinosis / complications,  diagnosis,  epidemiology*
Calcium / analysis
Cholesterol / blood
Cohort Studies
Coronary Disease / complications,  diagnosis,  epidemiology*
Coronary Vessels / chemistry
Diabetes Mellitus, Type 1 / complications*
Diabetes Mellitus, Type 2 / complications*
Female
Humans
Hypertension / complications
Male
Middle Aged
Risk Factors
Smoking
Tomography, X-Ray Computed
Chemical
Reg. No./Substance:
57-88-5/Cholesterol; 7440-70-2/Calcium
Comments/Corrections
Comment In:
Diabetes Care. 2001 Aug;24(8):1507-8   [PMID:  11473102 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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