Document Detail

Increased prevalence of regurgitant valvular heart disease in acromegaly.
MedLine Citation:
PMID:  14715829     Owner:  NLM     Status:  MEDLINE    
Cardiac involvement is common in acromegaly, but the prevalence of valvular abnormalities in patients with acromegaly has not been documented and is the topic of this study. In a prospective study design, 40 consecutive patients with acromegaly and 120 control subjects (matched for age, sex, hypertension, and left ventricular systolic function) were studied. All patients and controls were evaluated using conventional two-dimensional and Doppler echocardiography. Significant valve disease was more prevalent in acromegalics compared with controls (22% vs. 6.7%, respectively; P = 0.005). Aortic valve regurgitation (>/=>trace severity) was present in 30% of patients vs. 7% of controls (P < 0.001), and mitral regurgitation (>/=moderate severity) was absent in controls but present in 5% of acromegalics (P = 0.014 vs. controls). Binary logistic regression analysis showed a significant impact only for disease duration on valvular disease, with an odds ratio of 1.19 (95% confidence interval, 1.028-1.376; P = 0.019). Acromegaly is associated with an increased prevalence of regurgitant valvular heart disease. This is dependent on the duration of exposure to increased GH concentrations, with a 19% increase in odds per year. This increased prevalence of occult valvular disease indicates that these patients require appropriate follow-up care and monitoring, especially patients with inadequate control of GH overproduction.
Alberto M Pereira; Sjoerd W van Thiel; Jonathan R Lindner; Ferdinand Roelfsema; Ernst E van der Wall; Hans Morreau; Jan W A Smit; Johannes A Romijn; Jeroen J Bax
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  89     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-12     Completed Date:  2004-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  AIM; IM    
Department of Endocrinology and Metabolism, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
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MeSH Terms
Acromegaly / complications*
Aged, 80 and over
Aortic Valve Insufficiency / complications*,  epidemiology,  ultrasonography
Heart Valve Diseases / complications*
Logistic Models
Middle Aged
Mitral Valve Insufficiency / complications*,  epidemiology,  ultrasonography
Prospective Studies
Tricuspid Valve Insufficiency / complications*,  epidemiology,  ultrasonography
Ventricular Function, Left

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