| Increased prevalence of pervasive developmental disorders in children with slight arylsulfatase A deficiency. | |
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MedLine Citation:
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PMID: 12427515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arylsulfatase A deficiency (less than 15% of controls) is responsible for a neurological disorder known as metachromatic leukodystrophy. Nonetheless, low levels of the enzyme (15-50% of controls, higher than in metachromatic leukodystrophy) in adult patients have been related to neuropsychiatric disorders. On the other hand, there are only few and controversial data on the significance of reduced arylsulfatase A activity in children. This led us to perform the present study. Various classes of arylsulfatase A activity in children have been related with different groups of neuropsychiatric disorders and compared with a similar number of healthy children. We found a high percentage of reduced arylsulfatase A (less than 50% of controls) in children with pervasive developmental disorders (10.25%). Unexpectedly, raising the threshold level for considering arylsulfatase A deficiency up to 70% of controls resulted in a marked increase in the incidence of pervasive developmental disorders. This new class, arylsulfatase A slight deficiency, contained the highest number of patients affected by psychiatric symptoms. This suggests that arylsulfatase A slight deficiency could be a marker of a subclass of pervasive developmental disorders. |
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Authors:
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Maria Grazia Alessandri; Giuseppe De Vito; Francesco Fornai |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain & development Volume: 24 ISSN: 0387-7604 ISO Abbreviation: Brain Dev. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-12 Completed Date: 2003-01-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7909235 Medline TA: Brain Dev Country: Netherlands |
Other Details:
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Languages: eng Pagination: 688-92 Citation Subset: IM |
Copyright Information:
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Copyright 2002 Elsevier Science B.V. |
Affiliation:
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Division of Child Neurology and Psychiatry, IRCCS Stella Maris, Via dei Giacinti 2, I-56018 Calambrone, Pisa, Italy. mariagrazia.alessandri@inpe.unipi.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cerebroside-Sulfatase / deficiency* Child Child Development Disorders, Pervasive / enzymology*, epidemiology, etiology* Child, Preschool Female Humans Infant Male Prevalence |
| Chemical | |
Reg. No./Substance:
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EC 3.1.6.8/Cerebroside-Sulfatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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