| Increased prevalence of impaired fasting glucose in MEN1 gene mutation carriers. | |
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MedLine Citation:
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PMID: 21726266 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome characterized by parathyroid, gastroenteropancreatic, pituitary and adrenal tumours. Cardiovascular disease has been identified as an important cause of death in MEN1 patients. Menin, the product of the MEN1 gene, is a co-activator for peroxisome proliferator-activated receptor-γ and the vitamin D receptor, which are involved in glucose metabolism. We aimed to compare insulin sensitivity and prevalence of impaired fasting glucose and diabetes mellitus between MEN1 patients and controls. Design: Cross-sectional study Patients: Sixty-three MEN1 gene mutation carriers (44% males, mean age 41 years) from 22 kindreds and 126 unrelated controls matched for gender, age and BMI. Measurements: Fasting glucose levels were categorized and compared using WHO criteria. Homeostasis model assessment (HOMA) was used as a measure of insulin resistance. Results: HOMA was significantly increased in MEN1 patients compared with controls (3.0±2.0 versus 2.0±1.0, p<0.05). In MEN1 patients, HOMA was associated with BMI, but not with age, calcium and gastrin levels. Using logistic regression analysis, the presence of hyperparathyroidism, pancreatic lesions and various other manifestations was not associated with HOMA. Impaired fasting glucose was more prevalent in MEN1 compared with controls (18% versus 6%, p<0.05). Three MEN1 patients (5%) compared with four controls (3%) were diabetic (not significant). Conclusions: MEN1 patients had decreased insulin sensitivity and higher prevalence of impaired fasting glucose compared with controls, which was unrelated to MEN1 manifestations. Impaired glucose metabolism may result in increased risk of cardiovascular disease in MEN1 patients. |
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Authors:
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J P H van Wijk; K M A Dreijerink; C R C Pieterman; C J M Lips; P M J Zelissen; G D Valk |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-4 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine and Endocrinology, University Medical Center, Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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