Document Detail


Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients.
MedLine Citation:
PMID:  12742537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with autoimmune thyroiditis (AT) have an increased prevalence of coeliac disease (CD), an immune-mediated enteropathy. It is unknown, however, whether prevalence of CD in AT is affected by age. Sera from 514 patients with AT aged <65 yr (46+/-12 yr), 223 patients with AT aged >or=65 yr (71+/-5 yr), 300 controls aged <65 yr (45+/-12 yr), and 300 controls aged >or=65 yr (71+/-6 yr) were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). If anti-tTG or EmA IgA were positive, jejunal biopsy was performed to confirm CD diagnosis. Prevalence of CD was significantly higher in patients with AT aged >or=65 yr (3.6%, P=0.024) than in patients with AT aged <65 yr (0.6%), controls aged <65 yr and controls aged >or=65 yr (both 0.3%). Prevalence of CD did not significantly differ across patients with AT aged <65 yr, controls aged <65 yr and controls aged >or=65 yr. In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients.
Authors:
Giovanni Ravaglia; Paola Forti; Fabiola Maioli; Umberto Volta; Giorgia Arnone; Gaia Pantieri; Teresa Talerico; Antonio Muscari; Marco Zoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Experimental gerontology     Volume:  38     ISSN:  0531-5565     ISO Abbreviation:  Exp. Gerontol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-13     Completed Date:  2003-10-07     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  0047061     Medline TA:  Exp Gerontol     Country:  England    
Other Details:
Languages:  eng     Pagination:  589-95     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9, Bologna 40138, Italy. ravaglia@almadns.unibo.it
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Aging / immunology*
Autoantibodies / immunology
Celiac Disease / immunology*
Female
Gliadin / immunology
Humans
Immunoglobulin A / analysis
Immunoglobulin G / analysis
Male
Middle Aged
Thyroiditis, Autoimmune / complications,  immunology*
Transglutaminases / immunology
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases

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