| Increased prevalence of coeliac disease in autoimmune thyroiditis is restricted to aged patients. | |
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MedLine Citation:
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PMID: 12742537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with autoimmune thyroiditis (AT) have an increased prevalence of coeliac disease (CD), an immune-mediated enteropathy. It is unknown, however, whether prevalence of CD in AT is affected by age. Sera from 514 patients with AT aged <65 yr (46+/-12 yr), 223 patients with AT aged >or=65 yr (71+/-5 yr), 300 controls aged <65 yr (45+/-12 yr), and 300 controls aged >or=65 yr (71+/-6 yr) were tested for IgA anti-tissue transglutaminase (anti-tTG) and antiendomysial antibodies (EmA). If anti-tTG or EmA IgA were positive, jejunal biopsy was performed to confirm CD diagnosis. Prevalence of CD was significantly higher in patients with AT aged >or=65 yr (3.6%, P=0.024) than in patients with AT aged <65 yr (0.6%), controls aged <65 yr and controls aged >or=65 yr (both 0.3%). Prevalence of CD did not significantly differ across patients with AT aged <65 yr, controls aged <65 yr and controls aged >or=65 yr. In conclusion, prevalence of CD is increased in AT but the association is limited to patients aged 65 years or older. Serological screening including anti-tTG-IgA is recommended in these patients. |
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Authors:
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Giovanni Ravaglia; Paola Forti; Fabiola Maioli; Umberto Volta; Giorgia Arnone; Gaia Pantieri; Teresa Talerico; Antonio Muscari; Marco Zoli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Experimental gerontology Volume: 38 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-13 Completed Date: 2003-10-07 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: England |
Other Details:
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Languages: eng Pagination: 589-95 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Cardioangiology and Hepatology, University Hospital S. Orsola-Malpighi, Via Massarenti, 9, Bologna 40138, Italy. ravaglia@almadns.unibo.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aging / immunology* Autoantibodies / immunology Celiac Disease / immunology* Female Gliadin / immunology Humans Immunoglobulin A / analysis Immunoglobulin G / analysis Male Middle Aged Thyroiditis, Autoimmune / complications, immunology* Transglutaminases / immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Immunoglobulin A; 0/Immunoglobulin G; 9007-90-3/Gliadin; EC 2.3.2.13/Transglutaminases |
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