Document Detail

Increased prevalence of cardiovascular complications in women with furosemide resistant essential hypertension.
MedLine Citation:
PMID:  8512666     Owner:  NLM     Status:  MEDLINE    
Patients with essential hypertension (n = 2969) who had not been taking any blood pressure medication for longer than 1 week were classified as furosemide-sensitive (FS) if their diastolic BP after furosemide fell > or = 10% and furosemide-resistant (FR) if it fell less than that. The FS group was significantly (P < or = .05) older, and had higher blood pressure than the FR group. In patients over age 50, the prevalence of cardiovascular complications (myocardial infarction, stroke, angina, congestive heart failure, and intermittent claudication) in the FR group (12.3%) was significantly (P = .0039) more than in the FS group for all patients, and especially for women (P = .0053). This was not explained by plasma renin activity, plasma norepinephrine, obesity index, cholesterol, blood sugar, or smoking history, and was associated in the FR group with a lower BP. This study characterizes the furosemide response of BP in hypertensive subjects and demonstrates an increased prevalence of cardiovascular complications in women over age 50 in the furosemide resistant group.
G H Anderson; N Newman-Palmer; N Blakeman; D H Streeten
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  6     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-07-21     Completed Date:  1993-07-21     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  418-21     Citation Subset:  IM    
Department of Medicine, SUNY-HSC, Syracuse 13210.
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular Diseases / epidemiology,  etiology*
Drug Resistance
Furosemide / therapeutic use*
Hypertension / complications*,  drug therapy*
Middle Aged
Regression Analysis
Sex Characteristics*
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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