| Increased prevalence of antiheparin platelet factor 4 antibodies in patients may be due to contaminated heparin. | |
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MedLine Citation:
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PMID: 19357103 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During the period of November 2007 to January 2008, an increased prevalence of adverse reactions to heparin was noted. These adverse events have been attributed to the presence of purposeful contaminant, oversulfated chondroitin sulfate (OSCS) from April 2007 to May 2008. An analysis of dialysis patients' plasma obtained in 2006 and 2007 consistently had a low (5%) prevalence of AHPF4 antibodies. Blood samples from 78 patients on maintenance hemodialysis, who were potentially exposed to OSCS-contaminated heparin, were analyzed for the presence of all AHPF4 antibodies using a commercially available ELISA kit from GTI. Although there was no change in the platelet count of these patients, 15 of 78 patients (19.2%) studied had an increased prevalence of AHPF4 antibodies. Subtyping of the all platelet factor 4 (PF4) antibodies documented showed a higher prevalence of immunoglobulin G antibodies as compared to their previously determined antibodies. These observations suggest that the OSCS contaminant in the recalled heparin triggers an immunogenic response not seen with OSCS-contaminated free heparin. |
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Authors:
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Cafer Adiguzel; Vinod Bansal; Evangelos Litinas; Josephine Cunanan; Omer Iqbal; Kelly Nelson; Meganathan Kannan; Debra Hoppensteadt; Jawed Fareed |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis Volume: 15 ISSN: 1076-0296 ISO Abbreviation: Clin. Appl. Thromb. Hemost. Publication Date: 2009 Mar-Apr |
Date Detail:
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Created Date: 2009-04-09 Completed Date: 2009-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9508125 Medline TA: Clin Appl Thromb Hemost Country: United States |
Other Details:
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Languages: eng Pagination: 145-51 Citation Subset: IM |
Affiliation:
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Department of Pathology, Loyola University Medical Center, Maywood, Illinois 60153, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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blood*,
immunology Carbon Radioisotopes Chondroitin Sulfates / administration & dosage, poisoning* Drug Contamination* Enzyme-Linked Immunosorbent Assay Heparin / administration & dosage, chemistry* Humans Immunoglobulin G / blood, immunology Kidney Failure, Chronic / blood, therapy Platelet Aggregation / drug effects Platelet Count Platelet Factor 4 / immunology* Renal Dialysis / adverse effects Serotonin / metabolism Thrombocytopenia / blood*, chemically induced, immunology |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/Carbon Radioisotopes; 0/Immunoglobulin G; 37270-94-3/Platelet Factor 4; 50-67-9/Serotonin; 9005-49-6/Heparin; 9007-28-7/Chondroitin Sulfates |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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