Document Detail

Increased postperinatal child mortality among children of mothers exposed to measles during pregnancy.
MedLine Citation:
PMID:  2389757     Owner:  NLM     Status:  MEDLINE    
Previous studies of an urban and a rural epidemic in Guinea-Bissau have shown perinatal mortality to be statistically significantly higher among children whose mothers have been exposed to measles during pregnancy. After the epidemic in 1970 in Bandim, a district in the capital of Guinea-Bissau, such children also had a postperinatal childhood mortality risk (7 days to 5 years of age) of 0.229, compared with 0.134 for other children in the community. None of the mothers had developed clinical measles. In a Cox regression analysis adjusting for known background factors, the mortality hazard ratio between the exposed and the controls was found to be 2.0 (95% confidence interval 1.1-3.8). After a small rural measles epidemic in Quinhamel in 1983, the mortality hazard ratio for children of mothers exposed during pregnancy compared with controls was 1.7 (95% confidence interval 0.6-4.6). Exposure to measles or some concomitantly transmitted pathogen during fetal life may contribute to the high childhood mortality found in many developing countries.
P Aaby; E Seim; K Knudsen; J Bukh; I M Lisse; M C da Silva
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of epidemiology     Volume:  132     ISSN:  0002-9262     ISO Abbreviation:  Am. J. Epidemiol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7910653     Medline TA:  Am J Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-9     Citation Subset:  IM; J    
Institute of Anthropology, University of Copenhagen, Denmark.
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MeSH Terms
Child, Preschool
Follow-Up Studies
Gestational Age
Infant, Newborn
Measles / epidemiology*,  mortality
Prenatal Exposure Delayed Effects*
Regression Analysis
Sex Factors
Comment In:
Am J Epidemiol. 1991 Feb 15;133(4):413   [PMID:  1994707 ]

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