| Increased postabsorptive and exercise-induced whole-body glucose production in patients with chronic obstructive pulmonary disease. | |
| | |
MedLine Citation:
|
PMID: 21056887 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Skeletal muscle biopsy studies have consistently shown a decreased oxidative phenotype in patients with moderate to severe chronic obstructive pulmonary disease (COPD). Limited information is available regarding potential adaptations or abnormalities in anaerobic metabolism and glucose homeostasis. Whole-body glucose production was assessed at rest and during exercise in COPD patients with moderate disease severity (forced expiratory volume in 1 second, 52% ± 3%), prestratified into normal-weight (n = 7; body mass index [BMI], 27.5 ± 0.9 kg·m(-2)) and underweight subjects (n = 6; BMI, 20.6 ± 0.7 kg·m(-2)), and in 8 healthy controls matched for age and BMI with the normal-weight COPD group. Glucose tolerance was normal in all subjects. Rate of appearance (R(a)) of glucose at rest and during submaximal cycling exercise was measured in postabsorptive state by infusion of stable isotope tracer [6,6-(2)H(2)]glucose. Resting glucose R(a) was significantly enhanced in underweight COPD patients compared with controls (16.7 ± 0.3 vs 15.1 ± 0.4 μmol·kg fat-free mass(-1)·min(-1), P < .05) and was inversely related to fat-free mass (r = -0.75, P < .01). Furthermore, the exercise-induced increase in glucose R(a) was enhanced in COPD patients (81.9% ± 3.4% vs 72.1% ± 2.0%, P = .05), resulting in elevated end-of-exercise glucose output. Differences were most pronounced in underweight patients, who were also characterized by enhanced plasma catecholamine levels and decreased insulin concentrations (all, P < .05). In normal-weight patients, there was evidence for decreased insulin sensitivity assessed by homeostatic modeling technique. Whole-body glucose production is increased in underweight COPD patients with normal glucose tolerance. It is hypothesized that lowered body weight in COPD has unique effects on glucose uptake despite reduced skeletal muscle oxidative capacity, relative hypoxemia, and sympathetic activation. |
| | |
Authors:
|
Frits M E Franssen; Hans P Sauerwein; Mariette T Ackermans; Erica P A Rutten; Emiel F M Wouters; Annemie M W J Schols |
Related Documents
:
|
17381497 - The effects of metformin and glibenclamide on glucose metabolism, counter-regulatory ho... 2055837 - Changes in insulin response to glucose after exercise training in partially pancreatect... 10362627 - Glucose production during strenuous exercise in humans: role of epinephrine. 15048577 - The acute effects of exercise and glucose ingestion on circulating angiotensin-converti... 11289727 - Examination of the transtheoretical model and exercise in 3 populations. 12189127 - What are the signaling pathways used by norepinephrine to contract the artery? a demons... |
Publication Detail:
|
Type: Journal Article Date: 2010-11-05 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 60 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 957-64 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Respiratory Medicine, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Soluble leptin receptor and leptin are associated with baseline adiposity and metabolic risk factors...
Next Document: Computational analysis and identification of an emergent human adenovirus pathogen implicated in a r...