Document Detail

Increased portal tract infiltration of mast cells and eosinophils in primary biliary cirrhosis.
MedLine Citation:
PMID:  9399763     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Although recent reports demonstrate that eosinophilia is a distinctive feature of early stage primary biliary cirrhosis (PBC), the pathogenesis of this eosinophilia remains unknown. Clinical and experimental data suggest potential mast cell activation in cholestatic liver diseases. Because mast cell-derived mediators could induce eosinophil chemotaxis and activation, we hypothesized that mast cell activation may play a role in the pathogenesis of eosinophilia in PBC. Thus, as the first step in examining a possible link between mast cell activation and eosinophilia in PBC, we quantified the infiltration of mast cells and eosinophils in the livers of patients with PBC. METHODS: The study population consisted of 11 patients with stage I or stage II PBC and 11 patients with chronic viral hepatitis. Mast cells and eosinophils were identified by immunohistochemistry using monoclonal antibodies against mast cell tryptase (AA1) and eosinophilic cationic protein (EG2), respectively. Cell infiltration in the portal tract was quantitated morphometrically. RESULTS: When compared with patients with chronic viral hepatitis, patients with PBC showed significantly increased portal infiltration with mast cells (140 +/- 25 vs 72 +/- 10 cells/mm2 [mean +/- SEM, p < 0.05]) and eosinophils (76 +/- 19 vs 32 +/- 9 cells/mm2 [p < 0.05]). Numbers of portal mast cells correlated with numbers of eosinophils in patients with PBC (r = 0.60, p < 0.05) but not in patients with chronic hepatitis (r = 0.34, p = 0.47). CONCLUSION: Concomitant increases in mast cell and eosinophil infiltration in the portal tract suggest a role for mast cell activation in the pathogenesis of eosinophilia in PBC.
A Nakamura; K Yamazaki; K Suzuki; S Sato
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  92     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1997-12-29     Completed Date:  1997-12-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2245-9     Citation Subset:  IM    
First Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka, Japan.
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MeSH Terms
Antibodies, Monoclonal / diagnostic use
Blood Proteins / analysis
Cell Communication
Cell Count
Chemotaxis, Leukocyte
Cholestasis / pathology
Eosinophil Granule Proteins
Eosinophilia / immunology,  pathology
Eosinophils / immunology,  pathology*
Hepatitis, Chronic / pathology
Hepatitis, Viral, Human / pathology
Inflammation Mediators / analysis
Leukocyte Count
Liver / blood supply,  pathology
Liver Cirrhosis, Biliary / immunology,  pathology*
Mast Cells / immunology,  pathology*
Middle Aged
Portal System / pathology*
Serine Endopeptidases / analysis
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Blood Proteins; 0/Eosinophil Granule Proteins; 0/Inflammation Mediators; EC 3.1.-/Ribonucleases; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/chymase 2; EC; EC

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