| Increased polyploidy in aortic vascular smooth muscle cells during aging is marked by cellular senescence. | |
| | |
MedLine Citation:
|
PMID: 17291294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We previously reported that the frequency of polyploid aortic vascular smooth muscle cells (VSMC) serves as a biomarker of aging. Cellular senescence of somatic cells is another marker of aging that is characterized by the inability to undergo cell division. Here, we examined whether polyploidy is associated with the development of cellular senescence in vivo. Analysis of aortic tissue preparations from young and old Brown Norway rats showed that expression of senescence markers such as p16(INK4a) and senescence-associated beta-galactosidase activity are detected primarily in the old tissues. VSMC from p16(INK4a) knockout and control mice display similar levels of polyploid cells. Intriguingly, senescence markers are expressed in most, but not all, polyploid VSMC. Moreover, the polyploid cells exhibit limited proliferative capacity in comparison to their diploid counterparts. This study is the first to demonstrate in vivo that polyploid VSMC adopt a senescent phenotype. |
| | |
Authors:
|
Dan Yang; Donald J McCrann; Hao Nguyen; Cynthia St Hilaire; Ronald A DePinho; Matthew R Jones; Katya Ravid |
Related Documents
:
|
20525204 - Senescence evasion by mcf-7 human breast tumor-initiating cells. 310864 - Density of surface immunoglobulin and capping on rat b lymphocytes. i. changes with aging. 19855064 - Stress-induced senescence exaggerates postinjury neointimal formation in the old vascul... 2424654 - In-vitro studies of aging. 7982474 - Cell cycle-dependent nuclear localization of exogenously added fibroblast growth factor... 20525204 - Senescence evasion by mcf-7 human breast tumor-initiating cells. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-02-07 |
Journal Detail:
|
Title: Aging cell Volume: 6 ISSN: 1474-9718 ISO Abbreviation: Aging Cell Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-03-22 Completed Date: 2007-06-07 Revised Date: 2012-03-19 |
Medline Journal Info:
|
Nlm Unique ID: 101130839 Medline TA: Aging Cell Country: England |
Other Details:
|
Languages: eng Pagination: 257-60 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aorta / cytology Biological Markers / metabolism Cell Aging* Microscopy, Phase-Contrast Muscle, Smooth, Vascular / cytology* Myocytes, Smooth Muscle / cytology, metabolism* Phenotype Polyploidy* Rats |
| Grant Support | |
ID/Acronym/Agency:
|
AG022623/AG/NIA NIH HHS; R03 AG022623-01/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epithelia: lymphocyte interactions in the gut.
Next Document: Congenital melanocytic nevi and nevus spilus have a tendency to follow the lines of Blaschko: an exa...