Document Detail

Increased polyp detection using narrow band imaging compared with high resolution endoscopy in patients with hyperplastic polyposis syndrome.
MedLine Citation:
PMID:  21811939     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND AND STUDY AIMS: Hyperplastic polyposis syndrome (HPS) is associated with colorectal cancer and is characterized by multiple hyperplastic polyps, sessile serrated adenomas (SSAs) and adenomas. Narrow band imaging (NBI) may improve the detection of polyps in HPS. We aimed to compare polyp miss rates with NBI with those of high resolution endoscopy (HRE).
PATIENTS AND METHODS: In a single center, randomized crossover study consecutive HPS patients underwent tandem colonoscopy with HRE and NBI, in randomized order with removal of all detected polyps.
RESULTS: In 22 patients with HPS, 209 polyps were detected, including 27 with normal histology, 116 hyperplastic polyps, 42 SSAs, and 24 adenomas. Among patients assigned to HRE first (n = 11) a total of 78 polyps was detected; subsequent NBI added 44 polyps. In patients examined with NBI first, 78 polyps were detected and subsequent HRE added 9. Polyp miss rates of HRE and NBI were 36 % and 10 % (OR 0.21; 0.09 - 0.45). Flat polyp shape was independently associated with increased miss rate.
CONCLUSION: NBI significantly reduces polyp miss rates in HPS patients. We recommend using either NBI or chromoendoscopy for colonoscopic surveillance of HPS patients with removal of all detected polyps.
K S Boparai; F J van den Broek; S van Eeden; P Fockens; E Dekker
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Publication Detail:
Type:  Journal Article     Date:  2011-08-02
Journal Detail:
Title:  Endoscopy     Volume:  43     ISSN:  1438-8812     ISO Abbreviation:  Endoscopy     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215166     Medline TA:  Endoscopy     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  676-82     Citation Subset:  IM    
Copyright Information:
© Georg Thieme Verlag KG Stuttgart · New York.
Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands.
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