Document Detail

Increased platelet aggregability during exercise in patients with previous myocardial infarction. Lack of inhibition by aspirin.
MedLine Citation:
PMID:  10973679     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate the effects of acute exercise on platelet aggregability, blood coagulation, and fibrinolysis in patients with recent myocardial infarction, and to examine these effects in relation to two different antithrombotic regimens. Forty patients (mean age 60 years) were investigated 3 months after a myocardial infarction. They were randomized to antithrombotic treatment with either warfarin (INR 2.8-4.2) or aspirin 160 mg daily. They performed a standardized ergometer bicycle exercise test. Blood was drawn before and after the exercise. The platelet function tests included a platelet aggregate ratio (PAR), which, in the presence of aggregates, is<1. The coagulation products remained largely unchanged during the exercise, whereas the fibrinolytic activity and the catecholamine levels increased significantly. At baseline, PAR was lower in the warfarin group than in the aspirin group. During exercise, PAR was significantly reduced in both study groups (0.75 vs. 0.80), indicating increased platelet aggregability. Beta-thromboglobulin decreased in both groups. The increased platelet aggregability after exercise despite aspirin is probably due to activation by catecholamines. This implies that aspirin may have a limited antithrombotic effect during physical exercise and probably also in other situations with increased catecholamine levels.
M Hurlen; I Seljeflot; H Arnesen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Thrombosis research     Volume:  99     ISSN:  0049-3848     ISO Abbreviation:  Thromb. Res.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-04     Completed Date:  2000-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0326377     Medline TA:  Thromb Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  487-94     Citation Subset:  IM    
Dept of Cardiology, Ullevaal University Hospital, Oslo, Norway.
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MeSH Terms
Aspirin / administration & dosage,  pharmacology
Blood Coagulation Factors / drug effects
Fibrinolysis / drug effects
Hemostasis / drug effects
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  physiopathology*
Platelet Aggregation / drug effects*,  physiology
Warfarin / administration & dosage,  pharmacology
Reg. No./Substance:
0/Blood Coagulation Factors; 50-78-2/Aspirin; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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