Document Detail


Increased platelet activation and inflammatory response in patients with masked hypertension.
MedLine Citation:
PMID:  23358199     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Masked hypertension is associated with an increase in cardiovascular risk. Mean platelet volume (MPV), a determinant of platelet function, is a new risk factor for atherothrombosis. High-sensitive C-reactive protein (CRP) is an exquisitely sensitive systemic marker of inflammatory response. We designed this study to evaluate MPV and CRP in masked hypertensive patients and to compare those with essential hypertensive and healthy normotensive individuals. Forty-two untreated masked hypertensive patients, 53 untreated essential hypertensive patients and age-sex matched 37 normotensive healthy individuals were included in the study. Blood samples were collected and haematological parameters were measured. Plasma CRP level was measured by immunonephelometery method. The MPV was significantly higher in masked hypertensive (8.8 ± 1.6 fl) and essential hypertensive patients (9.1 ± 1.7 fl) than those of normotensive control individuals (7.8 ± 0.8 fl) (P = 0.01 and P = 0.003, respectively), whereas there was no significant difference between the masked hypertensive and essential hypertensive individuals (P > 0.05). CRP levels were also significantly higher in masked hypertensive patients than in normotensives individuals (3.31 ± 1.70, 1.98 ± 1.56 mg/l, P < 0.001, respectively). There was a significant positive correlation between MPV and CRP levels (P < 0.001, r = 0.850) in masked hypertensive patients. Patients with masked hypertension have higher MPV and CRP values than controls. Increased MPV and CRP levels may be the possible mechanisms behind the increased cardiovascular risk in masked hypertensive patients.
Authors:
Aytekin Guven; Mustafa Caliskan; Ozgur Ciftci; Irfan Barutcu
Related Documents :
23637959 - Hypertension and genetic variation in endothelial-specific genes.
23173589 - Device-based therapies for resistant hypertension.
24324489 - The association of postcardiac surgery acute kidney injury with intraoperative systolic...
1071689 - Cardiovascular effects of prazosin in dogs.
7305559 - Antihypertensive action of bromocriptine in neurogenic hypertensive dogs.
23286359 - Prevalence of chronic cardiovascular and metabolic diseases in senegalese workers: a cr...
8173749 - Effect of hypoxia on lung fluid balance in ferrets.
9285109 - Sexual dysfunction as an obstacle to compliance with antihypertensive therapy.
11437559 - Real atmosphere laboratory measurements of the 118-ghz oxygen line: shape, shift, and b...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  24     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-01-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  170-4     Citation Subset:  IM    
Affiliation:
aDepartment of Cardiology, Baskent University School of Medicine bDepartment of Cardiology, Meram Education and Research Hospital, Konya cDepartment of Cardiology, Avicenna Hospital, Istanbul, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Investigation of inherited thrombophilias in patients with pulmonary embolism.
Next Document:  Hepatic coagulopathy-intricacies and challenges; a cross-sectional descriptive study of 110 patients...